在多氯ocamphene作用下交感肾上腺系统状态的一些生物学指标研究。
Study of some biological indices of the state of the sympathoadrenaline system under the effect of polychlorocamphene.
作者信息
Kuz'minskaya U A, Ivanitskiĭ V A
出版信息
Environ Health Perspect. 1979 Jun;30:91-5. doi: 10.1289/ehp.793091.
The effect of exposure to different amounts of polychlorocamphene (toxaphene) on the level of cathecholamines (noradrenalin and adrenalin), their precursors (DOPA and dophamine), and a metabolite (vanillylmandelic acid) in tissues (adrenals, brain, heart) and daily urine in white male rats has been studied. It was established that the single administration of 120 mg/kg toxaphene (half the LD50) as well as 2.4 mg/kg (1/100 of LD50) for 1 and 3 months produced a disturbance of catecholamine metabolism. The absolute level of ratio of separate components of the sympathicoadrenalic system is unequally changed in tissues, the breakdown of catecholamines is increased, and the specificity of their excretion is destroyed.
研究了白雄性大鼠接触不同剂量的多氯樟脑（毒杀芬）对其组织（肾上腺、脑、心脏）和每日尿液中儿茶酚胺（去甲肾上腺素和肾上腺素）水平、它们的前体（多巴和多巴胺）以及一种代谢物（香草扁桃酸）的影响。结果表明，单次给予120mg/kg毒杀芬（半数致死剂量的一半）以及2.4mg/kg（半数致死剂量的1/100），持续1个月和3个月，会导致儿茶酚胺代谢紊乱。交感肾上腺系统各单独组分的绝对水平在组织中的变化不均衡，儿茶酚胺的分解增加，其排泄特异性遭到破坏。
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