Lange W, Kühnelt W, Alert H J, Schuffenhauer W
Arch Exp Veterinarmed. 1974;28(5):759-68.
Oral administration of 5 mg mestranol daily for 100 days to 70 German Black Peid bulls improved weight gain in 72% of the animals. Average additional increment ranged from 2 to 17%. During the first weeks of administration there was a weak and transient protein-anabolic action and improvement in digestion of crude protein. Appetite was slightly stimulated. Consumption of food and energy per unit of weight gain was improved; better growth led to higher slaughter weight. Treatment had no effect on meat to bone ratio, degree of fulness of the gastointestinal tract, or meat quality. Skeletal mineralization was improved by 10-30%, and there was a noticeable anabolic effect on mineral metabolism. After longer administration an antigonadotropic action became evident. Some veterinary indications for use in fattening cattle were derived from these effects. Further pharmacological and clinical investigation of this and more active anabolics seemed to be required.
对70头德国黑佩德公牛每日口服5毫克炔雌醇甲醚，持续100天，72%的动物体重增加。平均额外增幅为2%至17%。给药的最初几周，有微弱且短暂的蛋白质合成代谢作用，粗蛋白消化得到改善。食欲略有刺激。每单位体重增加的食物和能量消耗得到改善；更好的生长导致更高的屠宰体重。治疗对肉骨比、胃肠道饱满程度或肉质没有影响。骨骼矿化提高了10%至30%，对矿物质代谢有明显的合成代谢作用。长期给药后，抗促性腺激素作用变得明显。从这些效果中得出了一些用于育肥牛的兽医适应症。似乎需要对这种及更有效的合成代谢药物进行进一步的药理学和临床研究。
