大鼠肝脏中3,3',5,5'-四碘甲状腺原氨酸的鉴定。
The identification of 3,3', 5,5',-tetraiodothyroformic acid within the rat liver.
作者信息
Ramsden D B, Lawson A M, Raw P J, Hoffenberg R
出版信息
Biochem J. 1974 Oct;143(1):47-50. doi: 10.1042/bj1430047.
Abstract
Homogenized rat livers were extracted with organic solvents and the extracts converted into more readily volatile derivatives (trimethylsilylmethyl esters and permethyl esters). Combined g.l.c.-mass-spectrometric analysis identified the presence of tetraiodothyroformate. It is postulated that mitochondrial beta-oxidation of tetraiodothyropyruvate results in the formation of this apparently undescribed metabolite.
摘要
将大鼠肝脏匀浆用有机溶剂萃取，提取物转化为更易挥发的衍生物（三甲基硅甲酯和全甲酯）。气相色谱 - 质谱联用分析确定了四碘甲状腺原氨酸盐的存在。据推测，四碘甲状腺丙酮酸的线粒体β氧化导致了这种明显未被描述过的代谢产物的形成。
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本文引用的文献
1
I131-labeled 1-thyroxine. II. Nature of the excretion product in bile.
J Biol Chem. 1952 Feb;194(2):655-68.
2
The identification of the acetic acid analogues of thyroxine and tri-iodothyronine in mammalian tissues.
Biochem J. 1959 Jun;72(2):319-21. doi: 10.1042/bj0720319.
3
[Biliary excretion of a sulfoconjugate of 3,5,3'-triiodo-L-thyronine (T-3) after administration of this hormone to the rat].
C R Hebd Seances Acad Sci. 1957 Sep 23;245(13):1089-91.
4
[Biliary excretion of sulfaconjugated 3,3',5-triiodothyroacetic acid after administration in rats].
C R Hebd Seances Acad Sci. 1957 Aug 5;245(6):748-50.
5
Metabolism of L-thyroxine and L-3:5:3'-triiodothyronine by brain tissue preparations.
Endocrinology. 1957 Jan;60(1):83-98. doi: 10.1210/endo-60-1-83.
6
Enterohepatic circulation of thyroxine in humans.
Clin Sci. 1956 Nov;15(4):551-5.
7
[The nature of iodinated compounds excreted by liver and kidneys after administration of L-thyroxin and L-3,5,3'-triiodothyronine].
Biochim Biophys Acta. 1954 Dec;15(4):500-7. doi: 10.1016/0006-3002(54)90007-4.
8
The in-vitro deiodination of thyroxine and triiodothyronine.
Lancet. 1954 Aug 21;267(6834):368-9.
9
Gas chromatography of the trimethylsilyl derivatives of iodotyrosines and iodothyronines.
Anal Biochem. 1968 Feb;22(2):187-94. doi: 10.1016/0003-2697(68)90306-0.
10
GLC assay of sodium thyroxine.
J Pharm Sci. 1971 Mar;60(3):493-5. doi: 10.1002/jps.2600600341.
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