大鼠肝脏中3,3',5,5'-四碘甲状腺原氨酸的鉴定。
The identification of 3,3', 5,5',-tetraiodothyroformic acid within the rat liver.
作者信息
Ramsden D B, Lawson A M, Raw P J, Hoffenberg R
出版信息
Biochem J. 1974 Oct;143(1):47-50. doi: 10.1042/bj1430047.
Abstract
Homogenized rat livers were extracted with organic solvents and the extracts converted into more readily volatile derivatives (trimethylsilylmethyl esters and permethyl esters). Combined g.l.c.-mass-spectrometric analysis identified the presence of tetraiodothyroformate. It is postulated that mitochondrial beta-oxidation of tetraiodothyropyruvate results in the formation of this apparently undescribed metabolite.
摘要
将大鼠肝脏匀浆用有机溶剂萃取，提取物转化为更易挥发的衍生物（三甲基硅甲酯和全甲酯）。气相色谱 - 质谱联用分析确定了四碘甲状腺原氨酸盐的存在。据推测，四碘甲状腺丙酮酸的线粒体β氧化导致了这种明显未被描述过的代谢产物的形成。
相似文献
1
The identification of 3,3', 5,5',-tetraiodothyroformic acid within the rat liver.大鼠肝脏中3,3',5,5'-四碘甲状腺原氨酸的鉴定。
Biochem J. 1974 Oct;143(1):47-50. doi: 10.1042/bj1430047.
2
Effect of exercise on tissue levels of thyroid hormones in the rat.
Am J Physiol. 1971 Oct;221(4):1139-43. doi: 10.1152/ajplegacy.1971.221.4.1139.
3
Slow fractional removal of nonextractable iodine from rat tissue after injection of labeled L-thyroxine and 3,5,3'-triiodo-L-thyronine. A possible clue to the mechanism of initiation and persistence of hormonal action.注射标记的L-甲状腺素和3,5,3'-三碘-L-甲状腺原氨酸后，大鼠组织中非可提取碘的缓慢分次清除。这可能是激素作用启动和持续机制的一个线索。
J Clin Invest. 1972 Nov;51(11):2796-807. doi: 10.1172/JCI107102.
4
Effect of tetraiodothyroformic acid on oxygen consumption of the cholesterol-thiouracil-fed rat.四碘甲状腺原氨酸对喂食胆固醇-硫脲的大鼠耗氧量的影响。
Am J Physiol. 1959 Apr;196(4):857-8. doi: 10.1152/ajplegacy.1959.196.4.857.
5
Thyroid hormone deiodination pathways in brain and liver of rainbow trout, Oncorhynchus mykiss.虹鳟（Oncorhynchus mykiss）脑和肝脏中的甲状腺激素脱碘途径。
Gen Comp Endocrinol. 1996 Mar;101(3):323-32. doi: 10.1006/gcen.1996.0035.
6
Thyroid hormone metabolism in cultured hepatocytes.
Prog Clin Biol Res. 1981;74:57-66.
7
[The metabolism of thyroid hormones and its clinical applications].[甲状腺激素的代谢及其临床应用]
Rev Prat. 1979 Feb 21;29(11):979-80, 983-4, 987-8.
8
Thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (PFOS).给予成年大鼠口服全氟辛烷磺酸（PFOS）后的甲状腺激素状态和垂体功能。
Toxicology. 2008 Jan 20;243(3):330-9. doi: 10.1016/j.tox.2007.10.014. Epub 2007 Oct 26.
9
Thyroid hormones in the adult rat lung.成年大鼠肺中的甲状腺激素。
Am Rev Respir Dis. 1978 Apr;117(4):807-10. doi: 10.1164/arrd.1978.117.4.807.
10
Thyroid hormones and iodine metabolism.甲状腺激素与碘代谢。
Annu Rev Biochem. 1954;23:481-500. doi: 10.1146/annurev.bi.23.070154.002405.
引用本文的文献
1
The Colorful Diversity of Thyroid Hormone Metabolites.甲状腺激素代谢物的丰富多样性
Eur Thyroid J. 2019 Jun;8(3):115-129. doi: 10.1159/000497141. Epub 2019 May 21.
本文引用的文献
1
I131-labeled 1-thyroxine. II. Nature of the excretion product in bile.碘-131标记的甲状腺素。二、胆汁中排泄产物的性质。
J Biol Chem. 1952 Feb;194(2):655-68.
2
The identification of the acetic acid analogues of thyroxine and tri-iodothyronine in mammalian tissues.哺乳动物组织中甲状腺素和三碘甲状腺原氨酸醋酸类似物的鉴定。
Biochem J. 1959 Jun;72(2):319-21. doi: 10.1042/bj0720319.
3
[Biliary excretion of a sulfoconjugate of 3,5,3'-triiodo-L-thyronine (T-3) after administration of this hormone to the rat].[给大鼠注射3,5,3'-三碘-L-甲状腺原氨酸（T-3）后其硫酸结合物的胆汁排泄情况]
C R Hebd Seances Acad Sci. 1957 Sep 23;245(13):1089-91.
4
[Biliary excretion of sulfaconjugated 3,3',5-triiodothyroacetic acid after administration in rats].[大鼠给药后磺胺结合的3,3',5-三碘甲状腺乙酸的胆汁排泄]
C R Hebd Seances Acad Sci. 1957 Aug 5;245(6):748-50.
5
Metabolism of L-thyroxine and L-3:5:3'-triiodothyronine by brain tissue preparations.脑组织制剂对L-甲状腺素和L-3:5:3'-三碘甲状腺原氨酸的代谢
Endocrinology. 1957 Jan;60(1):83-98. doi: 10.1210/endo-60-1-83.
6
Enterohepatic circulation of thyroxine in humans.甲状腺素在人体中的肠肝循环。
Clin Sci. 1956 Nov;15(4):551-5.
7
[The nature of iodinated compounds excreted by liver and kidneys after administration of L-thyroxin and L-3,5,3'-triiodothyronine].[给予L-甲状腺素和L-3,5,3'-三碘甲状腺原氨酸后肝脏和肾脏排泄的碘化化合物的性质]
Biochim Biophys Acta. 1954 Dec;15(4):500-7. doi: 10.1016/0006-3002(54)90007-4.
8
The in-vitro deiodination of thyroxine and triiodothyronine.甲状腺素和三碘甲状腺原氨酸的体外脱碘作用。
Lancet. 1954 Aug 21;267(6834):368-9.
9
Gas chromatography of the trimethylsilyl derivatives of iodotyrosines and iodothyronines.
Anal Biochem. 1968 Feb;22(2):187-94. doi: 10.1016/0003-2697(68)90306-0.
10
GLC assay of sodium thyroxine.甲状腺素钠的葡萄糖醛酸转移酶测定
J Pharm Sci. 1971 Mar;60(3):493-5. doi: 10.1002/jps.2600600341.
Zotero 插件