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D-α-氨基己二酸对猫脊髓背角神经元生理诱发反应的影响。

Effects of D-alpha-aminoadipate on physiologically evoked responses of cat dorsal horn neurones.

作者信息

Davies J, Dray A

出版信息

Experientia. 1979 Mar 15;35(3):353-4. doi: 10.1007/BF01964348.

DOI:10.1007/BF01964348
PMID:446614
Abstract

Microelectrophoretic administration of D-alpha-aminoadipate reversibly reduced excitatory responses of cat dorsal horn neurones evoked by iontophoretic glutamate and non-noxious peripheral stimuli but did not influence similar responses evoked by noxious peripheral stimuli or iontophoretic substance P.

摘要

微电泳给予D-α-氨基己二酸可可逆地降低由离子电泳谷氨酸和非伤害性外周刺激诱发的猫背角神经元的兴奋性反应,但不影响由伤害性外周刺激或离子电泳P物质诱发的类似反应。

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1
Effects of D-alpha-aminoadipate on physiologically evoked responses of cat dorsal horn neurones.D-α-氨基己二酸对猫脊髓背角神经元生理诱发反应的影响。
Experientia. 1979 Mar 15;35(3):353-4. doi: 10.1007/BF01964348.
2
Selective antagonism of amino acid-induced and synaptic excitation in the cat spinal cord.猫脊髓中氨基酸诱导的和突触兴奋的选择性拮抗作用。
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3
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Effects of DL-alpha-aminoadipate on synaptically and chemically evoked excitation of anteroventral cochlear nucleus neurons of the cat.DL-α-氨基己二酸对猫耳蜗腹侧前核神经元突触性和化学性诱发兴奋的影响。
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Eur J Pharmacol. 1977 Oct 1;45(3):315-6. doi: 10.1016/0014-2999(77)90017-6.
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Neurosci Lett. 1980 Jan;16(1):17-20. doi: 10.1016/0304-3940(80)90094-4.
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D-alpha-aminoadipate, alpha, epsilon-diominopimelic acid and HA-966 as antagonists of amino acid-induced and synpatic excitation of mammalian spinal neurones in vivo.D-α-氨基己二酸、α,ε-二氨基庚二酸和HA-966作为体内氨基酸诱导的和哺乳动物脊髓神经元突触兴奋的拮抗剂。
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D-alpha-Aminoadipate as a selective antagonist of amino acid-induced and synaptic excitation of mammalian spinal neurones.D-α-氨基己二酸作为氨基酸诱导的和哺乳动物脊髓神经元突触兴奋的选择性拮抗剂。
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The action of D-alpha-aminoadipate on excitatory amino acid receptors of rat thalamic neurones.D-α-氨基己二酸对大鼠丘脑神经元兴奋性氨基酸受体的作用。
Brain Res. 1978 Jun 30;149(2):541-5. doi: 10.1016/0006-8993(78)90501-2.

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Selective antinociceptive effects of tizanidine (DS 103-282), a centrally acting muscle relaxant, on dorsal horn neurones in the feline spinal cord.中枢性肌肉松弛剂替扎尼定(DS 103 - 282)对猫脊髓背角神经元的选择性抗伤害感受作用。
Br J Pharmacol. 1984 Jun;82(2):409-21. doi: 10.1111/j.1476-5381.1984.tb10776.x.
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An ionophoretic study of the responses of rat caudal trigeminal nucleus neurones to non-noxious mechanical sensory stimuli.大鼠尾侧三叉神经核神经元对非伤害性机械感觉刺激反应的离子电泳研究。
J Physiol. 1982 Jun;327:65-78. doi: 10.1113/jphysiol.1982.sp014220.
3
The role of N-methylaspartate receptors in mediating responses of rat and cat spinal neurones to defined sensory stimuli.

本文引用的文献

1
Distribution of some synaptic transmitter suspects in cat spinal cord: glutamic acid, aspartic acid, gamma-aminobutyric acid, glycine and glutamine.猫脊髓中一些疑似突触递质的分布:谷氨酸、天冬氨酸、γ-氨基丁酸、甘氨酸和谷氨酰胺。
J Neurochem. 1967 Apr;14(4):465-72. doi: 10.1111/j.1471-4159.1967.tb09545.x.
2
Spinal interneurone excitation by conformationally restricted analogues of L-glutamic acid.L-谷氨酸构象受限类似物对脊髓中间神经元的兴奋作用。
Nature. 1974 Apr 26;248(5451):804-5. doi: 10.1038/248804a0.
3
The differential sensitivity of spinal interneurones and Renshaw cells to Kainate and N-methyl-D-aspartate.
N-甲基-D-天冬氨酸受体在介导大鼠和猫脊髓神经元对特定感觉刺激的反应中的作用。
J Physiol. 1987 Apr;385:169-88. doi: 10.1113/jphysiol.1987.sp016490.
4
Selective antagonism of amino acid-induced and synaptic excitation in the cat spinal cord.猫脊髓中氨基酸诱导的和突触兴奋的选择性拮抗作用。
J Physiol. 1979 Dec;297(0):621-35. doi: 10.1113/jphysiol.1979.sp013060.
脊髓中间神经元和闰绍细胞对海人酸和N-甲基-D-天冬氨酸的差异敏感性。
Exp Brain Res. 1974;21(5):515-8. doi: 10.1007/BF00237169.
4
Amino acid transmitters in the mammalian central nervous system.哺乳动物中枢神经系统中的氨基酸递质。
Ergeb Physiol. 1974;69(0):97-188. doi: 10.1007/3-540-06498-2_3.
5
Effects of substance P on functionally identified units in cat spinal cord.P物质对猫脊髓中功能确定神经元的作用。
Brain Res. 1976 Sep 24;114(3):439-51. doi: 10.1016/0006-8993(76)90965-3.
6
Effect of substance P in cat dorsal horn neurones activated by noxious stimuli.P物质对由伤害性刺激激活的猫脊髓背角神经元的作用。
Brain Res. 1977 Jun 3;128(1):164-9. doi: 10.1016/0006-8993(77)90245-1.
7
The actions of certain amino acids as neuronal excitants [proceedings].某些氨基酸作为神经元兴奋剂的作用[会议论文集]
J Physiol. 1977 Oct;272(1):52P-53P.
8
Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P.对可能与疼痛和镇痛相关的肽通路的免疫组织化学分析:脑啡肽和P物质。
Proc Natl Acad Sci U S A. 1977 Jul;74(7):3081-5. doi: 10.1073/pnas.74.7.3081.
9
D-alpha-aminoadipate, alpha, epsilon-diominopimelic acid and HA-966 as antagonists of amino acid-induced and synpatic excitation of mammalian spinal neurones in vivo.D-α-氨基己二酸、α,ε-二氨基庚二酸和HA-966作为体内氨基酸诱导的和哺乳动物脊髓神经元突触兴奋的拮抗剂。
Brain Res. 1978 Jun 16;148(2):543-8. doi: 10.1016/0006-8993(78)90745-x.
10
Pharmacological and electrophysiological studies of morphine and enkephalin on rat supraspinal neurones and cat spinal neurones.吗啡和脑啡肽对大鼠脊髓上神经元及猫脊髓神经元的药理学与电生理学研究。
Br J Pharmacol. 1978 May;63(1):87-96. doi: 10.1111/j.1476-5381.1978.tb07778.x.