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氯米帕明对豚鼠心室纤维的电生理作用。

Electrophysiological actions of chlorimipramine on guinea-pig ventricular fibres.

作者信息

Tamargo J, Rodriguez S

出版信息

Experientia. 1979 Mar 15;35(3):366-7. doi: 10.1007/BF01964356.

DOI:10.1007/BF01964356
PMID:446618
Abstract

Chlorimipramine (CMI, 1 x 10(-5)M to 7 X 10(-5)M) decreased the amplitude, overshoot and rate of rise of ventricular action potentials and abolished the Ca-mediated action potentials elicited in guinea-pig papillary muscles. These results indicates that CMI inhibits the rise in sodium and calcium conductances during the cardiac action potential.

摘要

氯米帕明(CMI,1×10⁻⁵M至7×10⁻⁵M)降低了豚鼠乳头肌心室动作电位的幅度、超射值和上升速率,并消除了钙介导的动作电位。这些结果表明,氯米帕明抑制心脏动作电位期间钠电导和钙电导的升高。

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本文引用的文献

1
Effects of calcium ions and local anesthetics on electrical properties of Purkinje fibres.钙离子和局部麻醉药对浦肯野纤维电特性的影响。
J Physiol. 1955 Sep 28;129(3):568-82. doi: 10.1113/jphysiol.1955.sp005379.
2
Cardiac complications of tricyclic antidepressant therapy.三环类抗抑郁药治疗的心脏并发症
Ann Intern Med. 1971 Mar;74(3):395-8. doi: 10.7326/0003-4819-74-3-395.
3
Membrane currents in mammalian ventricular heart muscle fibers using a voltage-clamp technique.运用电压钳技术对哺乳动物心室肌纤维膜电流的研究。
三环类抗抑郁药阿莫沙平对哺乳动物离体心脏标本电生理特性的抑制作用。
Br J Pharmacol. 1988 Aug;94(4):1250-6. doi: 10.1111/j.1476-5381.1988.tb11645.x.
J Gen Physiol. 1971 Mar;57(3):290-6. doi: 10.1085/jgp.57.3.290.
4
The slow inward current and the action of manganese ions in guinea-pig's myocardium.豚鼠心肌中的缓慢内向电流及锰离子的作用。
Pflugers Arch. 1970;316(1):81-94. doi: 10.1007/BF00587898.
5
Cardiovascular abnormalities following tricyclic antidepressant drug overdosage.三环类抗抑郁药过量服用后的心血管异常。
Drugs. 1974;7(5):323-5. doi: 10.2165/00003495-197407050-00002.
6
Divalent cations as charge carriers in excitable membranes.二价阳离子作为可兴奋膜中的电荷载体。
Prog Biophys Mol Biol. 1973;26:1-43. doi: 10.1016/0079-6107(73)90016-3.
7
A review of the cardiovascular effects and toxicity of tricyclic antidepressants.三环类抗抑郁药的心血管效应与毒性综述。
Psychosom Med. 1975 Mar-Apr;37(2):160-79. doi: 10.1097/00006842-197503000-00006.
8
Electrophysiological effects of droperidol in different cardiac tissues.氟哌利多对不同心脏组织的电生理效应。
Naunyn Schmiedebergs Arch Pharmacol. 1976;293(1):57-66. doi: 10.1007/BF00498871.
9
Reconstruction of the action potential of ventricular myocardial fibres.心室肌纤维动作电位的重建。
J Physiol. 1977 Jun;268(1):177-210. doi: 10.1113/jphysiol.1977.sp011853.
10
Clinical features in poisonings by tricyclic antidepressants with special reference to the ECG.三环类抗抑郁药中毒的临床特征,特别提及心电图表现
Acta Med Scand. 1976;199(5):337-44. doi: 10.1111/j.0954-6820.1976.tb06745.x.