氯米帕明对豚鼠心室纤维的电生理作用。
Electrophysiological actions of chlorimipramine on guinea-pig ventricular fibres.
作者信息
Tamargo J, Rodriguez S
出版信息
Experientia. 1979 Mar 15;35(3):366-7. doi: 10.1007/BF01964356.
PMID:446618
Abstract
Chlorimipramine (CMI, 1 x 10(-5)M to 7 X 10(-5)M) decreased the amplitude, overshoot and rate of rise of ventricular action potentials and abolished the Ca-mediated action potentials elicited in guinea-pig papillary muscles. These results indicates that CMI inhibits the rise in sodium and calcium conductances during the cardiac action potential.
摘要
氯米帕明（CMI，1×10⁻⁵M至7×10⁻⁵M）降低了豚鼠乳头肌心室动作电位的幅度、超射值和上升速率，并消除了钙介导的动作电位。这些结果表明，氯米帕明抑制心脏动作电位期间钠电导和钙电导的升高。
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