二氯甲烷对大鼠坐骨神经运动传导速度的影响。
Effect of dichloromethane on the sciatic motor conduction velocity of rats.
作者信息
Pankow D, Gutewort R, Ponsold W, Glatzel W, Tietze K
出版信息
Experientia. 1979 Mar 15;35(3):373-4. doi: 10.1007/BF01964361.
PMID:446623
Abstract
There is a correlation between dichloromethane dosis (X) of 1--6 mmole/kg administered i.p. to rats and the sciatic motor conduction velocity (Y): Y = 57.1--1.091 X. The correlation coefficient 'r' is 0.437 (p less than 0.01). Presumably, the decrease of nerve conduction velocity is caused by the endogenous carbon monoxide production due to dichloromethane biotransformation.
摘要
给大鼠腹腔注射剂量为1 - 6毫摩尔/千克的二氯甲烷（X）与坐骨神经运动传导速度（Y）之间存在相关性：Y = 57.1 - 1.091X。相关系数“r”为0.437（p < 0.01）。据推测，神经传导速度的降低是由于二氯甲烷生物转化产生内源性一氧化碳所致。
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