Glatzel W, Tietze K, Gutewort R, Pankow D
Clinic and Policlinic of Psychiatry and Neurology, Martin-Luther University, Halle, G. D. R.
Alcohol Clin Exp Res. 1987 Oct;11(5):450-2. doi: 10.1111/j.1530-0277.1987.tb01921.x.
The influence of a single combined administration of ethanol (174 mmol/kg per os) plus dichloromethane (1.6, 6.2, or 15.6 mmol/kg p.o.) on blood concentrations of the tested substances and of carboxyhemoglobin, and on nerve conduction velocity was studied in rats. The blood alcohol concentration was not influenced significantly by dichloromethane. The single high dose of ethanol completely inhibited the carboxyhemoglobin concentration increase due to dichloromethane, but did not prevent the dichloromethane-induced decrease of nerve conduction velocity. It produced initially lower, then higher concentrations of dichloromethane in blood than values seen after administration of dichloromethane per se. Rats treated with ethanol plus dichloromethane showed a more pronounced decrease of nerve conduction velocity compared with rats administered dichloromethane only.
研究了单次联合给予乙醇（174毫摩尔/千克，经口）加二氯甲烷（1.6、6.2或15.6毫摩尔/千克，经口）对大鼠受试物质和碳氧血红蛋白的血药浓度以及神经传导速度的影响。二氯甲烷对血乙醇浓度无显著影响。单次高剂量乙醇完全抑制了由二氯甲烷引起的碳氧血红蛋白浓度升高，但未能阻止二氯甲烷诱导的神经传导速度降低。与单独给予二氯甲烷相比，给予乙醇加二氯甲烷的大鼠血液中二氯甲烷浓度最初较低，随后较高。与仅给予二氯甲烷的大鼠相比，给予乙醇加二氯甲烷的大鼠神经传导速度下降更为明显。
