动脉粥样硬化内膜和成纤维细胞培养物中的胆碱酯酶。
Cholinesterase in the atherosclerotic intima and in fibroblast cultures.
作者信息
Kutty K M, Murphy D M, O'Donnell J, Chu M I
出版信息
Experientia. 1979 Mar 15;35(3):377-8. doi: 10.1007/BF01964363.
PMID:446625
Abstract
Cholinesterase activity was present in the atheromatous plaque of the rabbit's atherosclerotic aorta. Cholinesterase activity was significantly increased in rat fibroblast cultures grown in the presence of hypercholesterolemic serum. Cholesterol ester synthesis in these cultures was inhibited by neostigmine, a cholinesterase inhibitor.
摘要
胆碱酯酶活性存在于兔动脉粥样硬化主动脉的动脉粥样斑块中。在高胆固醇血症血清存在的情况下培养的大鼠成纤维细胞中，胆碱酯酶活性显著增加。在这些培养物中，胆固醇酯合成受到胆碱酯酶抑制剂新斯的明的抑制。
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