Esiri M M, MacLennan I C
Clin Exp Immunol. 1974 May;17(1):139-50.
An allergic myositis was produced in an inbred strain of rats by giving repeated injections of heterologous muscle with complete Freund's adjuvant. Histological lesions developed after two or more injections. The activity in the serum of the enzyme creatine phosphokinase (CPK) was found to be elevated after two injections and reached maximum levels after three to six injections. Transfer of lymphoid cells from spleen, lymph node or thoracic duct, after five immunizing injections resulted in the development of lesions in syngeneic recipients 5–10 days later. The lesions were milder than in the donors, but did result in elevation of the serum CPK activity in the recipients. It is concluded that measurement of the serum CPK activity is a convenient and objective reflection of the histological lesions produced in experimental allergic myositis.
通过向近交系大鼠反复注射异源肌肉与完全弗氏佐剂，诱发了过敏性肌炎。在注射两次或更多次后出现组织学损伤。发现肌酸磷酸激酶（CPK）血清活性在注射两次后升高，并在注射三至六次后达到最高水平。在进行五次免疫注射后，将来自脾脏、淋巴结或胸导管的淋巴细胞转移至同基因受体，5至10天后受体出现损伤。这些损伤比供体中的损伤轻，但确实导致受体血清CPK活性升高。结论是，血清CPK活性的测定是实验性过敏性肌炎中产生的组织学损伤的方便且客观的反映。
