Loebis L H
Arzneimittelforschung. 1979;29(12):1853-7.
The anti-fibrillatory ED50-values of a series of agents were determined. Upon administration of the agents in this ED50-dose (all agents then being equieffective in their antifibrillatory action) various side effects of each of them were quantitatively measured. The measured side effects were: the negative inotropic and chronotropic action, the conduction retarding, refractory period prolonging, excitability decreasing and ectopic automaticity depressing action. The substrate for these measurements was the isolated perfused rat heart. The series of agents tested consisted of a group possessing a beta-adrenolytic component and a group in which this component was absent. We compared quantitatively the side effects induced by the one group with those induced by the other. Differences were found in their influence on contractility and conductivity but not in their influence on the other parameters. The results obtained do not support the expectation that a beta-adrenolytic component will enlarge the therapeutic range of an antifibrillatory agent.
测定了一系列药物的抗纤颤半数有效剂量（ED50值）。以该ED50剂量给药这些药物（此时所有药物在抗纤颤作用方面等效）后，对每种药物的各种副作用进行了定量测量。所测量的副作用包括：负性肌力和变时作用、传导阻滞、不应期延长、兴奋性降低以及异位自律性抑制作用。这些测量的实验对象是离体灌流大鼠心脏。所测试的一系列药物包括一组含有β - 肾上腺素能阻断成分的药物和一组不含该成分的药物。我们对一组药物引起的副作用与另一组药物引起的副作用进行了定量比较。发现它们在对收缩性和传导性的影响方面存在差异，但在对其他参数的影响方面没有差异。所获得的结果不支持β - 肾上腺素能阻断成分会扩大抗纤颤药物治疗范围的预期。
