硝普钠：理论与实践
Sodium nitroprusside: theory and practice.
作者信息
Verner I R
出版信息
Postgrad Med J. 1974 Sep;50(587):576-81. doi: 10.1136/pgmj.50.587.576.
Abstract
Sodium nitroprusside, by a peripheral vasodilator action, is a powerful hypotensive drug. In contrast to established agents, its hypotensive action is accompanied by an unchanged or augmented cardiac output. Intravenous administration of sodium nitroprusside rapidly produces a profound and controllable hypotension. Normotension is swiftly restored by ceasing to infuse the agent, and antidotes are unnecessary. Its attributes make it especially suitable for neurosurgical anaesthesia, and although free cyanide is liberated during biotransformation, side effects are virtually absent provided that dosage is reasonable. Special contraindications to its use are hypothyroidism and altered cobalamin metabolism.
摘要
硝普钠是一种强效降压药，通过外周血管舒张作用起效。与已有的药物不同，其降压作用伴随着心输出量不变或增加。静脉注射硝普钠可迅速产生显著且可控的低血压。停止输注该药物后血压能迅速恢复正常，无需使用解毒剂。其特性使其特别适用于神经外科麻醉，尽管在生物转化过程中会释放游离氰化物，但只要剂量合理，几乎没有副作用。其使用的特殊禁忌证为甲状腺功能减退和钴胺素代谢改变。
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Sodium nitroprusside: theory and practice.硝普钠：理论与实践
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Conversion of thiocyanate to cyanide by an erythrocytic enzyme.红细胞酶将硫氰酸盐转化为氰化物。
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Sodium nitroprusside in the surgical treatment of cerebral aneurysms and arteriovenous malformations.硝普钠在脑动脉瘤和动静脉畸形手术治疗中的应用
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Sodium nitroprusside as a hypotensive agent in general anaesthesia.
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Sodium nitroprusside as a hypotensive agent.硝普钠作为一种降压药。
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Haemodynamic effects of sodium nitroprusside during nitrous oxide-halothane anaesthesia.
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