与口服避孕药相关的巨幼细胞贫血。
Megaloblastic anaemia associated with the oral contraceptive pill.
作者信息
Meguid M M, Loebl W Y
出版信息
Postgrad Med J. 1974 Jul;50(585):470-72. doi: 10.1136/pgmj.50.585.470.
A 27-year-old housewife suffered from severe headaches for a period of 2 years which developed after she started taking an oral contraceptive pill. During this time she gradually developed folic acid deficiency anaemia. This resulted from the inhibition by ‘the pill’ of the intestinal conjugase system required to deconjugate polyglutamic folate. The patient's headache did not recur after stopping the pill and her anaemia improved with folic acid supplement. The relation between folic acid metabolism and ‘the pill’ is discussed.
一名27岁的家庭主妇在开始服用口服避孕药后出现了严重头痛，持续了2年。在此期间，她逐渐患上了叶酸缺乏性贫血。这是由于避孕药抑制了肠道内将多聚谷氨酸叶酸去共轭所需的共轭酶系统。患者停药后头痛未再复发，补充叶酸后贫血状况有所改善。本文讨论了叶酸代谢与避孕药之间的关系。
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