口服避孕药：对叶酸和维生素B12代谢的影响
Oral contraceptives: effect of folate and vitamin B12 metabolism.
作者信息
Shojania A M
出版信息
Can Med Assoc J. 1982 Feb 1;126(3):244-7.
Abstract
Women who use oral contraceptives have impaired folate metabolism as shown by slightly but significantly lower levels of folate in the serum and the erythrocytes and an increased urinary excretion of formiminoglutamic acid. The vitamin B12 level in their serum is also significantly lower than that of control groups. However, there is no evidence of tissue depletion of vitamin B12 associated with the use of oral contraceptives. The causes and clinical significance of the impairment of folate and vitamin B12 metabolism in these women is discussed in this review of the literature. Clinicians are advised to ensure that women who shop taking "the pill" because they wish to conceive have adequate folate stores before becoming pregnant.
摘要
使用口服避孕药的女性叶酸代谢受损，表现为血清和红细胞中的叶酸水平略有但显著降低，以及尿中亚胺甲基谷氨酸排泄增加。她们血清中的维生素B12水平也显著低于对照组。然而，没有证据表明使用口服避孕药会导致维生素B12的组织耗竭。本文献综述讨论了这些女性叶酸和维生素B12代谢受损的原因及临床意义。建议临床医生确保那些因希望怀孕而停止服用“避孕药”的女性在怀孕前有足够的叶酸储备。
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