一些关于吲哚拉明的临床药理学研究及其治疗效用观察。
Some clinical pharmacological studies with indoramin, with observations on its therapeutic usefulness.
作者信息
de White C, Royds R B, Turner P
出版信息
Postgrad Med J. 1974 Dec;50(590):729-33. doi: 10.1136/pgmj.50.590.729.
Abstract
In the treatment of fifteen patients with essential hypertension, in open trial indoramin caused a mean blood pressure fall from 180/115 mmHg to 159/98 mmHg. No reversal of antihypertensive effect was seen in four patients after additions of the tricyclic antidepressant drug desipramine. Blood pressure did not begin to rise in these four patients for at least 5 weeks after stopping indoramin. The implications of these findings are discussed.
摘要
在一项开放性试验中，对15例原发性高血压患者使用吲哚拉明治疗后，平均血压从180/115毫米汞柱降至159/98毫米汞柱。在加用三环类抗抑郁药地昔帕明后，4例患者未出现抗高血压作用的逆转。在停用吲哚拉明后，这4例患者的血压至少5周未开始升高。本文讨论了这些发现的意义。
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