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The binding of 14C labelled 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) to macromolecules of sensitive and resistant tumours.

作者信息

Connors T A, Hare J R

出版信息

Br J Cancer. 1974 Nov;30(5):477-80. doi: 10.1038/bjc.1974.224.

DOI:10.1038/bjc.1974.224
PMID:4469198
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2009303/
Abstract
摘要

相似文献

1
The binding of 14C labelled 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) to macromolecules of sensitive and resistant tumours.14C标记的1-（2-氯乙基）-3-环己基-1-亚硝基脲（CCNU）与敏感和耐药肿瘤大分子的结合
Br J Cancer. 1974 Nov;30(5):477-80. doi: 10.1038/bjc.1974.224.
2
Binding of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea to L1210 cell nuclear proteins.1-（2-氯乙基）-3-环己基-1-亚硝基脲与L1210细胞核蛋白的结合
Cancer Res. 1976 Apr;36(4):1470-4.
3
Inhibition of RNA synthesis in murine ependymoblastoma by the combination of amphotericin B and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.两性霉素B与1-(2-氯乙基)-3-环己基-1-亚硝基脲联合使用对小鼠室管膜母细胞瘤RNA合成的抑制作用
Cancer Res. 1980 Mar;40(3):939-42.
4
Relationship of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) pharmacokinetics of uptake, distribution, and tissue/plasma partitioning in rat organs and intracerebral tumors.1,3-双（2-氯乙基）-1-亚硝基脲（卡莫司汀，BCNU）与1-（2-氯乙基）-3-环己基-1-亚硝基脲（洛莫司汀，CCNU）在大鼠器官和脑肿瘤中的摄取、分布及组织/血浆分配的药代动力学关系
Cancer Chemother Pharmacol. 1978;1(4):233-42. doi: 10.1007/BF00257156.
5
Active site specific inactivation of chymotrypsin by cyclohexyl isocyanate formed during degradation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.在抗癌药物1-(2-氯乙基)-3-环己基-1-亚硝基脲降解过程中形成的环己基异氰酸酯对胰凝乳蛋白酶的活性位点特异性失活作用。
Biochemistry. 1977 Apr 19;16(8):1584-9. doi: 10.1021/bi00627a009.
6
[Varying rate of destruction of alkylated molecules of RNA, protein and lipids in normal and neoplastic cells].[正常细胞和肿瘤细胞中RNA、蛋白质及脂质烷基化分子的不同破坏速率]
Biull Eksp Biol Med. 1973 Nov;76(11):64-7.
7
Modification of CCNU pharmacokinetics by misonidazole--a major mechanism of chemosensitization in mice.米索硝唑对洛莫司汀药代动力学的影响——小鼠化学增敏的主要机制
Br J Cancer. 1983 May;47(5):659-69. doi: 10.1038/bjc.1983.104.
8
Mechanism of uptake of nitrosoureas by L5178Y lymphoblasts in vitro.L5178Y淋巴母细胞在体外摄取亚硝基脲的机制。
Cancer Res. 1977 Apr;37(4):1022-7.
9
Potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by amphotericin B in murine ependymoblastoma.两性霉素B对小鼠室管膜母细胞瘤中1-(2-氯乙基)-3-环己基-1-亚硝基脲的增效作用
Cancer Res. 1976 Nov;36(11 Pt 1):4069-73.
10
Stereoselective monooxygenation of carcinostatic 1-(2-chloroethyl)-3-(cyclohexyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea by purified cytochrome P-450 isozymes.纯化的细胞色素P-450同工酶对抑癌药物1-(2-氯乙基)-3-(环己基)-1-亚硝基脲和1-(2-氯乙基)-3-(反式-4-甲基环己基)-1-亚硝基脲的立体选择性单加氧作用。
Biochem Pharmacol. 1984 Feb 15;33(4):609-13. doi: 10.1016/0006-2952(84)90316-2.

引用本文的文献

1
The hepatotoxicity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in rats. Ultrastructural evidence of a delayed microtubular toxicity.
Cancer Chemother Pharmacol. 1988;22(2):153-62. doi: 10.1007/BF00257314.

本文引用的文献

1
MICROBIOLOGICAL EVALUATION OF 1,3-BIS (2-CHLOROETHYL)-I-NITROSOUREA.
Cancer Res. 1964 Aug;24:1222-8.
2
Experimental evaluation of potential anticancer agents VIII. Effects of certain nitrosoureas on intracerebral L1210 leukemia.潜在抗癌剂的实验评估VIII. 某些亚硝基脲对脑内L1210白血病的影响
Cancer Res. 1963 Jun;23:725-33.
3
The modes of decomposition of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds.
J Med Chem. 1967 Jul;10(4):668-74. doi: 10.1021/jm00316a033.
4
Alkylating activity of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds.
J Med Chem. 1967 Mar;10(2):259-61. doi: 10.1021/jm00314a032.
5
Comparison of nitrogen-mustard sensitive and -resistant Yoshida sarcomas.氮芥敏感型与耐药型吉田肉瘤的比较。
Int J Cancer. 1966 Jul 15;1(4):319-27. doi: 10.1002/ijc.2910010403.
6
Some effects of 1, 3-bis(2-chloroethyl)-1-nitrosourea upon the synthesis of protein and nucleic acids in vivo and in vitro.1,3-双（2-氯乙基）-1-亚硝基脲对体内和体外蛋白质及核酸合成的某些影响。
Cancer Res. 1965 Nov;25(10):1770-8.
7
Effect of 1,3-bis-(2-chloroethyl)-1-nitrosourea on Saccharomyces cerevisiae.1,3-双（2-氯乙基）-1-亚硝基脲对酿酒酵母的作用。
Proc Soc Exp Biol Med. 1965 Aug-Sep;119(4):1004-10. doi: 10.3181/00379727-119-30361.
8
Comparative effects of the antitumor agents 5-(Dimethyltriazeno)-imidazole-4-carboxamide and 1,3-bis(2-chloroethyl)-1-nitrosourea on cell cycle of L1210 leukemia cells in vivo.抗肿瘤药物5-（二甲基三氮烯）-咪唑-4-甲酰胺和1,3-双（2-氯乙基）-1-亚硝基脲对L1210白血病细胞体内细胞周期的比较作用
Cancer Res. 1970 Aug;30(8):2173-90.
9
Effects of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; NSC-79037) and its degradation products on progression of L1210 cells through the cell cycle.
Cancer Chemother Rep. 1971 Jun;55(3):215-20.
10
Collateral sensitivity of resistant lines of mouse leukemias L1210 and L5178Y.
Cancer Res. 1972 Apr;32(4):808-12.