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Alkylating activity of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds.

作者信息

Wheeler G P, Chumley S

出版信息

J Med Chem. 1967 Mar;10(2):259-61. doi: 10.1021/jm00314a032.

DOI:10.1021/jm00314a032
PMID:6034073
Abstract
摘要

相似文献

1
Alkylating activity of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds.
J Med Chem. 1967 Mar;10(2):259-61. doi: 10.1021/jm00314a032.
2
Evaluation of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) in the management of patients with advanced breast cancer.
Cancer Chemother Rep. 1972 Feb;56(1):93-4.
3
Treatment of advanced Hodgkin's disease with (1,3 bis (2-chloroethyl)-1-nitrosourea) BCNU.
N Engl J Med. 1971 Aug 26;285(9):475-9. doi: 10.1056/NEJM197108262850902.
4
Combined therapy with cytosine arabinoside (NSC-63878) and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) for advanced solid tumors.
Cancer Chemother Rep. 1972 Feb;56(1):53-9.
5
Enhancement of the antitumor effect of 1,3-bis(2-chloroethyl)-1-nitrosourea by vitamin A and caffeine.
J Natl Cancer Inst. 1972 Apr;48(4):927-32.
6
Enhancement of the antitumor effects of 1,3-bis(2-chloroethyl)-1-nitrosourea and cyclophosphamide by vitamin A.
J Natl Cancer Inst. 1972 Apr;48(4):921-6.
7
Phase II study of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) in the treatment of bronchogenic carcinoma.
Cancer Chemother Rep. 1972 Apr;56(2):259-61.
8
Gas-chromatographic determination of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (methyl-CCNU). Part III. Denitrosation to the parent urea.
Analyst. 1982 May;107(1274):556-65. doi: 10.1039/an9820700556.
9
Some effects of 1, 3-bis(2-chloroethyl)-1-nitrosourea upon the synthesis of protein and nucleic acids in vivo and in vitro.1,3-双(2-氯乙基)-1-亚硝基脲对体内和体外蛋白质及核酸合成的某些影响。
Cancer Res. 1965 Nov;25(10):1770-8.
10
2-chloroethanol formation as evidence for a 2-chloroethyl alkylating intermediate during chemical degradation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea and 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea.2-氯乙醇的形成作为1-(2-氯乙基)-3-环己基-1-亚硝基脲和1-(2-氯乙基)-3-(反式-4-甲基环己基)-1-亚硝基脲化学降解过程中2-氯乙基烷基化中间体的证据。
Cancer Res. 1975 Mar;35(3):568-76.

引用本文的文献

1
When alcohol is the answer: Trapping, identifying and quantifying simple alkylating species in aqueous environments.当答案是酒精时:在水环境中捕获、识别和量化简单烷基化物质。
Anal Biochem. 2016 Sep 1;508:34-7. doi: 10.1016/j.ab.2016.04.020. Epub 2016 May 14.
2
The binding of 14C labelled 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) to macromolecules of sensitive and resistant tumours.14C标记的1-(2-氯乙基)-3-环己基-1-亚硝基脲(CCNU)与敏感和耐药肿瘤大分子的结合
Br J Cancer. 1974 Nov;30(5):477-80. doi: 10.1038/bjc.1974.224.
3
Antineoplastic drugs in 1990. A review (Part II).
1990年的抗肿瘤药物。综述(第二部分)。
Drugs. 1990 May;39(5):652-73. doi: 10.2165/00003495-199039050-00003.