Olson N D, Nuttall F Q, Sinha A, Kilo C, Williamson J R
Diabetes. 1979 Jul;28(7):686-9. doi: 10.2337/diab.28.7.686.
Muscle capillary basement membrane width (MCBMW) was measured in 18 myotonic dystrophy patients and compared with that in age- and sex-matched normal and diabetic subjects. The MCBMW in myotonic dystrophy patients (773 +/- 258 A) was significantly thinner than in normal subjects (925 +/- 181 A, P less than 0.05) or in diabetics (1224 +/- 614 A, P less than 0.01). An increase in MCBMW with advancing age was present in all groups but was greatest in the myotonic dystrophy groups (r = +0.59, P less than 0.01). There was no relation between MCBMW and either the degree of glucose intolerance or insulin hypersecretion in the myotonic dystrophy group, though none had fasting hyperglycemia. This is the first report of a condition associated with thinner-than-normal capillary basement membrane.
对18例强直性肌营养不良患者测量了肌肉毛细血管基底膜宽度（MCBMW），并与年龄和性别匹配的正常人和糖尿病患者进行了比较。强直性肌营养不良患者的MCBMW（773±258埃）明显薄于正常受试者（925±181埃，P<0.05）或糖尿病患者（1224±614埃，P<0.01）。所有组中MCBMW均随年龄增长而增加，但在强直性肌营养不良组中增加最为显著（r = +0.59，P<0.01）。在强直性肌营养不良组中，MCBMW与葡萄糖耐量程度或胰岛素分泌过多均无关联，尽管所有患者均无空腹血糖过高情况。这是首次报道与毛细血管基底膜比正常薄相关的病症。
