Wilson W A, Wachtel H
Science. 1974 Dec 6;186(4167):932-4. doi: 10.1126/science.186.4167.932.
Voltage clamping giving step commands reveals a steady-state negative resistance characteristic in the current-voltage curves of Aplysia bursting neurons. This is observed below spike threshold in the unstable range through which the membrane potential slowly oscillates. The negative resistance characteristic underlies this instability and shapes the rapid depolarization-hyper-polarization phase of the cycle. When bursting cells are converted to silent cells (by cooling) the negative resistance is abolished; conversely, when normally silent cells are made to burst (by warming) a negative resistance develops. The presence of negative resistance thus enables the bursting cell to oscillate, whereas its absence precluldes such oscillations.
给予阶跃指令的电压钳制揭示了海兔爆发性神经元电流-电压曲线中的稳态负电阻特性。这一特性在低于动作电位阈值的不稳定范围内被观察到，在此范围内膜电位会缓慢振荡。负电阻特性是这种不稳定性的基础，并塑造了该周期中快速去极化-超极化阶段。当爆发性细胞转变为静息细胞时（通过冷却），负电阻消失；相反，当正常的静息细胞被诱导爆发时（通过升温），负电阻则会出现。因此，负电阻的存在使爆发性细胞能够振荡，而其缺失则排除了这种振荡。
