Laron Z
Birth Defects Orig Artic Ser. 1974;10(4):231-8.
In 1966 we described a syndrome of familial dwarfism which was indistinguishable both clinically and in many of the laboratory findings from pituitary dwarfism, but in which there were abnormally high plasma concentrations of immunoreactive human growth hormone (IR-HGH). The possibility was raised that in these cases the circulating growth hormone is biologically inactive. Additional patients were described two years later, and in recent years we have reported additional clinical and laboratory findings in these and newly-discovered patients, all of whom were of Jewish origin. Subsequently, this syndrome was detected in non-Jewish populations.
1966年，我们描述了一种家族性侏儒症综合征，该综合征在临床和许多实验室检查结果上与垂体性侏儒症无法区分，但患者血浆中免疫反应性人生长激素（IR-HGH）浓度异常升高。由此推测，在这些病例中，循环中的生长激素可能没有生物活性。两年后又发现了更多患者，近年来我们报告了这些患者以及新发现患者的更多临床和实验室检查结果，他们均为犹太裔。随后，在非犹太人群中也发现了这种综合征。
