Chambers T J, Morson B C
Gut. 1979 Apr;20(4):269-74. doi: 10.1136/gut.20.4.269.
The number of granulomas in sections of bowel involved by Crohn's disease has been counted and related to length of previous history, treatment with steroids, site of involvement, and the subsequent course of the disease. It was found that a high content of granulomas predicted a good prognosis in the large bowel and anus, but was of no prognostic significance in the small bowel. A large regional variation in granuloma counts was observed from an average of 1 per section in the small bowel to 6 in the colon, 18 in the rectum, and 36 in the anus. Those patients with a long clinical history showed a low granuloma content. The findings are consistent with the view that the granuloma represents an adaptive mechanism for the removal or localisation of the causative agent of Crohn's disease.
对克罗恩病累及肠段切片中的肉芽肿数量进行了计数，并将其与既往病史时长、类固醇治疗情况、受累部位以及疾病后续病程相关联。结果发现，肉芽肿含量高预示着大肠和肛门的预后良好，但对小肠则无预后意义。观察到肉芽肿计数存在较大的区域差异，从小肠平均每切片1个到结肠6个、直肠18个、肛门36个不等。临床病史长的患者肉芽肿含量低。这些发现与以下观点一致，即肉芽肿代表了一种用于清除或定位克罗恩病病原体的适应性机制。
