Shulimzon Tiberiu, Rozenman Jehudit, Perelman Marina, Bardan Eytan, Ben-Dov Issahar
Pulmonary Institute, Sheba Medical Center affiliated to Sackler's School of Medicine, Tel Aviv University, Tel Hashomer, Israel.
Respiration. 2007;74(6):698-702. doi: 10.1159/000092854. Epub 2006 Apr 20.
Extraintestinal involvement, including the chest, is common in the late course of Crohn's disease. We describe 2 female patients in whom the course of the disease was unique in two aspects: (1) each had a pulmonary mass with granulomatous inflammation and necrosis, and (2) these findings had preceded the colonic involvement by 5 years. This sequence supports some of the theories on the pathogenesis of Crohn's disease and on its possible relation with sarcoidosis, another idiopathic granulomatous disease.
包括胸部在内的肠外受累在克罗恩病晚期很常见。我们描述了2例女性患者，她们的病程在两个方面很独特：（1）每位患者都有一个伴有肉芽肿性炎症和坏死的肺部肿块，（2）这些表现比结肠受累早5年。这一顺序支持了一些关于克罗恩病发病机制及其与结节病（另一种特发性肉芽肿性疾病）可能关系的理论。
