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Synthesis of 6-(phenylhydrazino)uracils and their inhibition of a replication-specific deoxyribonucleic acid polymerase.

作者信息

Wright G E, Brown N C

出版信息

J Med Chem. 1974 Dec;17(12):1277-82. doi: 10.1021/jm00258a009.

DOI:10.1021/jm00258a009
PMID:4473549
Abstract
摘要

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Synthesis of 6-(phenylhydrazino)uracils and their inhibition of a replication-specific deoxyribonucleic acid polymerase.6-(苯肼基)尿嘧啶的合成及其对复制特异性脱氧核糖核酸聚合酶的抑制作用。
J Med Chem. 1974 Dec;17(12):1277-82. doi: 10.1021/jm00258a009.
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Low molecular weight deoxyribonucleic acid polymerase from calf thymus chromatin. II. Initiation and fidelity of homopolymer replication.来自小牛胸腺染色质的低分子量脱氧核糖核酸聚合酶。II. 同聚物复制的起始与保真度。
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A comparative study of the effect of normal substrates and 5-iodo-2'-deoxyuridine triphosphate, a metabolic analog of thymidine triphosphate, on the inactivation of Escherichia coli deoxyribonucleic acid polymerase I and II by ultraviolet irradiation.正常底物与5-碘-2'-脱氧尿苷三磷酸(三磷酸胸腺嘧啶核苷的代谢类似物)对紫外线照射使大肠杆菌脱氧核糖核酸聚合酶I和II失活的影响的比较研究。
J Biol Chem. 1974 Feb 25;249(4):1239-46.
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Hydrolysis of template and newly synthesized deoxyribonucleic acid by the 3' to 5' exonuclease activity of the T4 deoxyribonucleic acid polymerase.T4 脱氧核糖核酸聚合酶的 3' 至 5' 核酸外切酶活性对模板及新合成的脱氧核糖核酸的水解作用。
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Inhibition of a DNA polymerase from Bacillus subtilis by hydroxyphenylazopyrimidines.羟基苯基偶氮嘧啶对枯草芽孢杆菌DNA聚合酶的抑制作用。
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Regulation of thymidine kinase activity by 5-iodo-2'-deoxyuridine 5'-triphosphate and deoxythymidine 5'-triphosphate.
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RSC Med Chem. 2025 Sep 3. doi: 10.1039/d5md00591d.
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The B. subtilis Accessory Helicase PcrA Facilitates DNA Replication through Transcription Units.枯草芽孢杆菌辅助解旋酶PcrA通过转录单元促进DNA复制。
PLoS Genet. 2015 Jun 12;11(6):e1005289. doi: 10.1371/journal.pgen.1005289. eCollection 2015 Jun.
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RecO and RecR are necessary for RecA loading in response to DNA damage and replication fork stress.
RecO 和 RecR 对于 RecA 在应对 DNA 损伤和复制叉压力时的加载是必要的。
J Bacteriol. 2014 Aug;196(15):2851-60. doi: 10.1128/JB.01494-14. Epub 2014 Jun 2.
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Development of novel inhibitor probes of DNA polymerase III based on dGTP analogs of the HPUra type: base, nucleoside and nucleotide derivatives of N2-(3,4-dichlorobenzyl)guanine.基于HPUra型dGTP类似物的新型DNA聚合酶III抑制剂探针的开发:N2-(3,4-二氯苄基)鸟嘌呤的碱基、核苷和核苷酸衍生物
Nucleic Acids Res. 1990 Dec 25;18(24):7381-7. doi: 10.1093/nar/18.24.7381.