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Pharmacological investigations of tylophorine, the major alkaloid of Tylophora indica.

作者信息

Gopalakrishnan C, Shankaranarayan D, Kameswaran L, Natarajan S

出版信息

Indian J Med Res. 1979 Mar;69:513-20.

PMID:447392
Abstract
摘要

相似文献

1
Pharmacological investigations of tylophorine, the major alkaloid of Tylophora indica.娃儿藤碱(印度娃儿藤的主要生物碱)的药理学研究。
Indian J Med Res. 1979 Mar;69:513-20.
2
Effect of tylophorine, a major alkaloid of Tylophora indica, on immunopathological and inflammatory reactions.
Indian J Med Res. 1980 Jun;71:940-8.
3
Left, right, or both? On the configuration of the phenanthroindolizidine alkaloid tylophorine from Tylophora indica.左、右、还是两者兼有?关于印度娃儿藤中菲烷吲哚里西啶生物碱千里光碱的构型。
J Nat Prod. 2013 Feb 22;76(2):275-8. doi: 10.1021/np300838w. Epub 2013 Jan 31.
4
Tylophorine arrests carcinoma cells at G1 phase by downregulating cyclin A2 expression.娃儿藤碱通过下调细胞周期蛋白A2的表达使癌细胞停滞于G1期。
Biochem Biophys Res Commun. 2009 Aug 14;386(1):140-5. doi: 10.1016/j.bbrc.2009.05.138. Epub 2009 Jun 6.
5
Tylophorine Abrogates G2/M Arrest Induced by Doxorubicine and Promotes Increased Apoptosis in T47D Breast Cancer Cells.娃儿藤碱消除阿霉素诱导的T47D乳腺癌细胞G2/M期阻滞并促进细胞凋亡增加。
Asian Pac J Cancer Prev. 2018 Nov 29;19(11):3065-3069. doi: 10.31557/APJCP.2018.19.11.3065.
6
Synthesis and biological evaluation of tylophorine-derived dibenzoquinolines as orally active agents: exploration of the role of tylophorine e ring on biological activity.托品烷衍生二苯并喹啉类化合物的合成及生物评价:托品烷 E 环对生物活性影响的研究
J Med Chem. 2012 Dec 13;55(23):10363-77. doi: 10.1021/jm300705j. Epub 2012 Dec 4.
7
Inhibition of cellular immune responses by Tylophora indica in experimental models.印度娃儿藤在实验模型中对细胞免疫反应的抑制作用。
Phytomedicine. 2001 Sep;8(5):348-55. doi: 10.1078/0944-7113-00055.
8
Synthesis and evaluation of the anti-proliferative and NF-κB activities of a library of simplified tylophorine analogs.简化穿心莲内酯类似物库的合成及抗增殖和 NF-κB 活性评价。
Bioorg Med Chem. 2012 Oct 1;20(19):5893-900. doi: 10.1016/j.bmc.2012.07.044. Epub 2012 Aug 3.
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A study of central pharmacological activity of alkaloid fraction of Apium graveolens Linn.芹菜生物碱部分的中枢药理活性研究
Indian J Med Res. 1970 Jan;58(1):99-102.
10
Anti-inflammatory effects of 7-methoxycryptopleurine and structure-activity relations of phenanthroindolizidines and phenanthroquinolizidines.7-甲氧基隐品碱的抗炎作用以及菲并吲哚里西啶和菲并喹诺里西啶的构效关系
Biochem Biophys Res Commun. 2007 Mar 23;354(4):942-8. doi: 10.1016/j.bbrc.2007.01.065. Epub 2007 Jan 22.

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Benzoindolizidine Alkaloids Tylophorine and Lycorine and Their Analogues with Antiviral, Anti-Inflammatory, and Anticancer Properties: Promises and Challenges.苯并吲哚里西啶生物碱娃儿藤碱和石蒜碱及其具有抗病毒、抗炎和抗癌特性的类似物:前景与挑战
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The antibacterial, phytochemicals and antioxidants evaluation of the root extracts of Hydnora africanaThunb. used as antidysenteric in Eastern Cape Province, South Africa.南非东开普省用作抗痢疾药物的非洲地蜂草(Hydnora africana Thunb.)根提取物的抗菌、植物化学物质及抗氧化剂评估。
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Reformulating Tylocrebrine in Epidermal Growth Factor Receptor Targeted Polymeric Nanoparticles Improves Its Therapeutic Index.
将泰勒克溴林重新配制于表皮生长因子受体靶向聚合物纳米颗粒中可提高其治疗指数。
Mol Pharm. 2015 Aug 3;12(8):2912-23. doi: 10.1021/acs.molpharmaceut.5b00173. Epub 2015 Jul 3.
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Tylophorine, a phenanthraindolizidine alkaloid isolated from Tylophora indica exerts antiangiogenic and antitumor activity by targeting vascular endothelial growth factor receptor 2-mediated angiogenesis.从 Tylophora indica 中分离得到的 phenanthraindolizidine 生物碱 tylophorine 通过靶向血管内皮生长因子受体 2 介导的血管生成发挥抗血管生成和抗肿瘤活性。
Mol Cancer. 2013 Jul 29;12:82. doi: 10.1186/1476-4598-12-82.
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Phenanthroindolizidines and Phenanthroquinolizidines: Promising Alkaloids for Anti-Cancer Therapy.菲并吲哚里西啶和菲并喹诺里西啶:用于抗癌治疗的有前景的生物碱。
Curr Bioact Compd. 2009 Mar 1;5(1):2-19. doi: 10.2174/157340709787580928.
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Total synthesis of (S)-(+)-tylophorine via enantioselective intramolecular alkene carboamination.通过对映选择性分子内烯烃碳胺化反应全合成(S)-(+)-娃儿藤碱
J Org Chem. 2008 Aug 1;73(15):6045-7. doi: 10.1021/jo801024h. Epub 2008 Jun 28.