Butterworth K R, Jarman D A
Br J Pharmacol. 1974 Jul;51(3):462-4. doi: 10.1111/j.1476-5381.1974.tb10685.x.
The alpha- and beta-adrenoceptor activities of the isolated rat uterus during the oestrous cycle were intluenced greatly by temperature changes. During dioestrus, lowering the bath temperature to 25 degrees C from 40 degrees C increased two-fold the inhibition produced by (-)-adrenaline, (-)-noradrenaline, (-)-phenylephrine and (-)-isoprenaline. During oestrus adrenaline, noradrenaline and phenylephrine produced biphasic responses of contraction followed by inhibition at 40 degrees C and isoprenaline produced only inhibition. At 25 degrees C the contractile alpha-responses either were abolished (phenylephrine) or greatly reduced (adrenaline and noradrenaline), while the inhibitory beta-effects of all four amines were increased.
在发情周期中，温度变化对离体大鼠子宫的α-和β-肾上腺素能受体活性有很大影响。在间情期，将浴温从40℃降至25℃，可使（-）-肾上腺素、（-）-去甲肾上腺素、（-）-去氧肾上腺素和（-）-异丙肾上腺素产生的抑制作用增加两倍。在发情期，肾上腺素、去甲肾上腺素和去氧肾上腺素在40℃时产生双相收缩反应，随后出现抑制作用，而异丙肾上腺素仅产生抑制作用。在25℃时，收缩性α反应要么被消除（去氧肾上腺素），要么大大降低（肾上腺素和去甲肾上腺素），而所有四种胺类的抑制性β效应均增强。
