产后大鼠子宫中肾上腺素能受体的性质。
The nature of the adrenoceptors in the post-partum rat uterus.
作者信息
Abdel-Aziz A, Bakry N
出版信息
Br J Pharmacol. 1972 Jul;45(3):504-9. doi: 10.1111/j.1476-5381.1972.tb08107.x.
Abstract
- Uteri were removed from rats 0.5 h to 8 days after parturition and were suspended in Locke solution at 37 degrees C.2. The agonists isoprenaline, adrenaline, noradrenaline and phenylephrine produced an inhibition of the post-partum rat uterus.3. In the presence of propranolol, the agonists noradrenaline, adrenaline, and phenylephrine had an excitatory effect on the post-partum rat uterus. This excitatory effect was blocked by phenoxybenzamine indicating that it is mediated through alpha-adrenoceptors.4. These excitatory alpha-adrenoceptors could be demonstrated for 5-6 days after parturition. By the 7th-8th days their existence was no longer apparent.5. Excitatory alpha-adrenoceptors were also demonstrated in the late pregnant rat uterus.
摘要
在大鼠分娩后0.5小时至8天内取出子宫，并将其悬浮于37℃的洛克溶液中。
激动剂异丙肾上腺素、肾上腺素、去甲肾上腺素和苯肾上腺素对产后大鼠子宫产生抑制作用。
在普萘洛尔存在的情况下，激动剂去甲肾上腺素、肾上腺素和苯肾上腺素对产后大鼠子宫有兴奋作用。这种兴奋作用被酚苄明阻断，表明它是通过α-肾上腺素能受体介导 的。
这些兴奋性α-肾上腺素能受体在分娩后5-6天可以被证实。到第7-8天，它们的存在不再明显。
在妊娠晚期大鼠子宫中也证实了兴奋性α-肾上腺素能受体。
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