洛哌丁胺（R 18 553），一种新型止泻剂。第5部分：洛哌丁胺在大鼠和人体中的药代动力学。 - Suppr

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超能文献

Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 5: the pharmacokinetics of loperamide in rats and man.

作者信息

Heykants J, Michiels M, Knaeps A, Brugmans J

出版信息

Arzneimittelforschung. 1974 Oct;24(10):1649-53.

PMID:4479779

Abstract

摘要

相似文献

Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 5: the pharmacokinetics of loperamide in rats and man.洛哌丁胺（R 18 553），一种新型止泻剂。第5部分：洛哌丁胺在大鼠和人体中的药代动力学。

Arzneimittelforschung. 1974 Oct;24(10):1649-53.

Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 8: Clinical investigation. Use of a flexible dosage schedule in a double-blind comparison of loperamide with diphenoxylate in 614 patients suffering from acute diarrhea.洛哌丁胺（R 18 553），一种新型止泻药。第八部分：临床研究。在614例急性腹泻患者中，采用灵活剂量方案对洛哌丁胺与地芬诺酯进行双盲比较。

Arzneimittelforschung. 1974 Oct;24(10):1660-5.

Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 4: studies on subacute and chronic toxicity and the effect on reproductive processes in rats, dogs and rabbits.洛哌丁胺（R 18 553），一种新型止泻药。第4部分：大鼠、狗和兔的亚急性和慢性毒性及对生殖过程影响的研究。

Arzneimittelforschung. 1974 Oct;24(10):1645-9.

Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 7: Clinical investigation. Efficacy and safety of loperamide in patients with severe chronic diarrhea.洛哌丁胺（R 18 553），一种新型止泻药。第7部分：临床研究。洛哌丁胺治疗严重慢性腹泻患者的疗效和安全性。

Arzneimittelforschung. 1974 Oct;24(10):1657-60.

Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 6: Clinical pharmacology. Placebo-controlled comparison of the constipating activity and safety of loperamide, diphenoxylate and codeine in normal volunteers.洛哌丁胺（R 18 553），一种新型止泻药。第6部分：临床药理学。正常志愿者中洛哌丁胺、地芬诺酯和可待因致便秘活性及安全性的安慰剂对照比较。

Arzneimittelforschung. 1974 Oct;24(10):1653-7.

Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 1: in vivo oral pharmacology and acute toxicity. Comparison with morphine, codeine, diphenoxylate and difenoxine.洛哌丁胺（R 18 553），一种新型止泻药。第1部分：体内口服药理学及急性毒性。与吗啡、可待因、地芬诺酯和地芬诺辛的比较。

Arzneimittelforschung. 1974 Oct;24(10):1633-6.

Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 3: in vitro studies on the peristaltic reflex and other experiments on isolated tissues.洛哌丁胺（R 18 553），一种新型止泻剂。第3部分：对蠕动反射的体外研究及对离体组织的其他实验。

Arzneimittelforschung. 1974 Oct;24(10):1641-5.

Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 2: in vivo parenteral pharmacology and acute toxicity in mice. Comparison with morphine, codeine and diphenoxylate.洛哌丁胺（R 18 553），一种新型止泻药。第2部分：小鼠体内非肠道药理学及急性毒性。与吗啡、可待因及地芬诺酯的比较。

Arzneimittelforschung. 1974 Oct;24(10):1636-41.

Absorption studies with the anti-diarrhoeal agent ethacridine lactate in laboratory animals and man.

Arzneimittelforschung. 1977;27(4):872-8.

In vivo antimotility and antidiarrheal activity of lidamidine hydrochloride (WHR-1142A), a novel antidiarrheal agent. Comparison with diphenoxylate and loperamide.新型止泻药盐酸利达米定（WHR-1142A）的体内抗蠕动和止泻活性。与地芬诺酯和洛哌丁胺的比较。

Arzneimittelforschung. 1978;28(8a):1448-54.

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Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics in Sprague-Dawley rats.P-糖蛋白和有机阴离子转运蛋白的竞争性底物对芬太尼和洛哌丁胺血-器官转运的影响存在差异：Sprague-Dawley大鼠的药代动力学和药效学研究

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Limited effects of beta-endorphin compared to loperamide or fentanyl in a neuroendocrine biomarker assay in non-human primates.在非人类灵长类动物的神经内分泌生物标志物检测中，与洛哌丁胺或芬太尼相比，β-内啡肽的作用有限。

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Interaction of ritonavir-boosted tipranavir with loperamide does not result in loperamide-associated neurologic side effects in healthy volunteers.利托那韦增强的替拉那韦与洛哌丁胺的相互作用不会在健康志愿者中导致与洛哌丁胺相关的神经副作用。

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