Nutt J, Clark F, Welch R G, Hall R
Br Med J. 1974 Dec 21;4(5946):695-6. doi: 10.1136/bmj.4.5946.695.
Neonatal hyperthyroidism has been thought to result from transplacental passage of long-acting thyroid stimulator (L.A.T.S.) from a mother with Graves's disease. A case is presented here in which no L.A.T.S. was detected in the mother or neonate but another immunoglobulin, L.A.T.S. protector, a specific human thyroid stimulator, was shown to be present in the mother's serum. This stimulator may have been the cause of the neonatal hyperthyroidism.
新生儿甲状腺功能亢进症一直被认为是由于长效甲状腺刺激素(LATS)通过胎盘从患有格雷夫斯病的母亲传递给胎儿所致。本文报告了一例病例,在母亲和新生儿体内均未检测到LATS,但发现母亲血清中存在另一种免疫球蛋白——LATS保护因子,一种特异性人类甲状腺刺激素。这种刺激素可能是导致新生儿甲状腺功能亢进症的原因。