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新生儿甲状腺功能亢进症与长效甲状腺刺激素保护剂

Neonatal hyperthyroidism and long-acting thyroid stimulator protector.

作者信息

Nutt J, Clark F, Welch R G, Hall R

出版信息

Br Med J. 1974 Dec 21;4(5946):695-6. doi: 10.1136/bmj.4.5946.695.

Abstract

Neonatal hyperthyroidism has been thought to result from transplacental passage of long-acting thyroid stimulator (L.A.T.S.) from a mother with Graves's disease. A case is presented here in which no L.A.T.S. was detected in the mother or neonate but another immunoglobulin, L.A.T.S. protector, a specific human thyroid stimulator, was shown to be present in the mother's serum. This stimulator may have been the cause of the neonatal hyperthyroidism.

摘要

新生儿甲状腺功能亢进症一直被认为是由于长效甲状腺刺激素(LATS)通过胎盘从患有格雷夫斯病的母亲传递给胎儿所致。本文报告了一例病例,在母亲和新生儿体内均未检测到LATS,但发现母亲血清中存在另一种免疫球蛋白——LATS保护因子,一种特异性人类甲状腺刺激素。这种刺激素可能是导致新生儿甲状腺功能亢进症的原因。

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本文引用的文献

1
Neonatal hyperthyroidism.
N Engl J Med. 1963 Feb 7;268:292-6. doi: 10.1056/NEJM196302072680606.
3
Radioimmunoassay of human serum thyrotrophin.人血清促甲状腺素的放射免疫测定
Br Med J. 1971 Mar 13;1(5749):582-5. doi: 10.1136/bmj.1.5749.582.
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Graves' disease--1972.格雷夫斯病——1972年。
Mayo Clin Proc. 1972 Nov;47(11):803-13.
9
Grades of hypothyroidism.甲状腺功能减退的分级。
Br Med J. 1973 Mar 17;1(5854):657-62. doi: 10.1136/bmj.1.5854.657.

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