苄环烷和氯氮䓬对脑内5-羟色胺更新及摄取的影响。
Effects of benzoctamine and chlordiazepoxide on turnover and uptake of 5-hydroxytryptamine in the brain.
作者信息
Lippmann W, Pugsley T A
出版信息
Br J Pharmacol. 1974 Aug;51(4):571-5. doi: 10.1111/j.1476-5381.1974.tb09676.x.
Abstract
1 Benzoctamine, a new psychoactive drug, known to exert in man an anti-anxiety effect resembling that of chlordiazepoxide, decreased the disappearance of intraventricularly-injected [(14)C]-5-hydroxytryptamine (5-HT) from rat brain, as did chlordiazepoxide.2 Both drugs partially inhibited the alpha-ethyl-3-hydroxy-4-methylphenylethylamine-induced depletion of rat brain 5-HT.3 It is concluded that benzoctamine, like chlordiazepoxide, decreases 5-HT turnover in the brain and that this action may play a role in the anti-anxiety effect of these drugs observed in man.
摘要
苄氯胺，一种新型精神活性药物，已知其在人体中产生的抗焦虑作用类似于氯氮卓，它能减少大鼠脑室内注射的[(14)C]-5-羟色胺（5-HT）从大鼠脑中的消失，氯氮卓也有同样的作用。
两种药物都部分抑制了α-乙基-3-羟基-4-甲基苯乙胺诱导的大鼠脑5-HT耗竭。
得出的结论是，苄氯胺与氯氮卓一样，会降低脑中5-HT的周转，并且这种作用可能在这些药物在人体中观察到的抗焦虑作用中发挥作用。
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