Clapp N K, Satterfield L C, Bowles N D
J Gerontol. 1979 Jul;34(4):497-501. doi: 10.1093/geronj/34.4.497.
Butylated hydroxytoluene (BHT) was given in the feed to determine its effect on life span in genetically well-defined, barrier-derived BALB/c mice. Both sexes received 0.75% BHT for three different treatment periods: (A) 8 to 11 weeks of age; (B) for life, beginning at 11 weeks; (C) for life, beginning at 8 weeks of age. The control group (D) was untreated. All BHT treatment groups had mean survival times which exceeded that of controls. The order of survival was B greater than C greater than A greater than D (Males: 890, 832, 726, 684 days; Females: 875, 798, 759, 701 days). Most of the increases in mean survival time were related to a reduction in early deaths (350--600 days) in BHT-treated mice. The reason for the life-lengthening effect on BHT was not identified, but it may relate to alterations in specific disease incidences.
在饲料中添加丁基羟基甲苯（BHT），以确定其对基因明确、来自屏障环境的BALB/c小鼠寿命的影响。雌雄小鼠均接受0.75%BHT，设置三个不同的处理时期：（A）8至11周龄；（B）从11周龄开始终生投喂；（C）从8周龄开始终生投喂。对照组（D）不进行处理。所有BHT处理组的平均存活时间均超过对照组。存活顺序为B＞C＞A＞D（雄性：890、832、726、684天；雌性：875、798、759、701天）。平均存活时间的增加大多与BHT处理小鼠早期死亡（350 - 600天）的减少有关。未确定BHT延长寿命的原因，但可能与特定疾病发病率的改变有关。
