人类嗜碱性粒细胞被动致敏的一些定量方面
Some quantitative aspects of the passive sensitization of human basophils.
作者信息
Goldstein B, Dembo M, Malveaux F J
出版信息
J Immunol. 1979 Mar;122(3):830-3.
PMID:448077
Abstract
We review the theory for the binding of IgE to Fc receptors on basophil surfaces. We then use the theory to analyze binding experiments of Malveaux et al. and T. Ishizaka on the passive sensitization of basophils from a patient with chronic myelocytic leukemia and 75% basophilia. From their data we determine that the forward rate constant for the binding of human IgE to receptors on these human basophils is (3.0 +/- 1.0) x 10(4) M-1 sec-1.
摘要
我们回顾了IgE与嗜碱性粒细胞表面Fc受体结合的理论。然后我们运用该理论分析了Malveaux等人以及T. Ishizaka关于一名慢性粒细胞白血病伴75%嗜碱性粒细胞增多症患者的嗜碱性粒细胞被动致敏的结合实验。根据他们的数据，我们确定人IgE与这些人嗜碱性粒细胞上受体结合的正向速率常数为(3.0±1.0)×10⁴ M⁻¹ 秒⁻¹。
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