Johnson K J, Varani J, Oliver J, Ward P A
J Immunol. 1979 May;122(5):1807-11.
Immune complex vasculitis has been induced in normal mice and in mice with features of the Chediak-Higashi syndrome ("beige" mice). The accumulation of neutrophils in peritoneal exudates after the injection of C5a is not quantitatively depressed in beige as compared with normal mice. Immune complex-induced vasculitis in these two strains of mice is not quantitatively different, as assessed by vascular damage (vasopermeability changes and histologic criteria). Measurements of leukocyte enzymes confirm the findings of Vassalli et al. that leukocytes of beige mice lack neutral protease activity. The data suggest that the neutral protease of murine leukocytes does not account for the vascular damage of immune complex vasculitis.
免疫复合物性血管炎已在正常小鼠和具有切-东综合征特征的小鼠（“米色”小鼠）中诱发。与正常小鼠相比，注射C5a后腹膜渗出物中中性粒细胞的积聚在米色小鼠中并未出现定量性降低。通过血管损伤（血管通透性变化和组织学标准）评估，这两种品系小鼠中免疫复合物诱导的血管炎在数量上并无差异。白细胞酶的测量结果证实了瓦萨利等人的发现，即米色小鼠的白细胞缺乏中性蛋白酶活性。数据表明，鼠白细胞的中性蛋白酶与免疫复合物性血管炎的血管损伤无关。
