Norwood T H, Hoehn H, Salk D, Martin G M
J Invest Dermatol. 1979 Jul;73(1):92-6. doi: 10.1111/1523-1747.ep12532778.
Werner's syndrome is commonly regarded as a model for the study of premature aging. There are, however, a variety of clinical and pathologic anatomical features that clearly distinguish it from aging in normal individuals. In this paper we report on in vitro cytogenetic and cell fusion studies that indicate cultured fibroblast-like cells derived from Werner patients differ from cells of normal donors. Despite these discordances with "natural" aging, however, Werner's syndrome, like several other "segmental progeroid syndromes," may prove useful for the investigation of selected aspects of the aging process and of age-related diseases.
韦尔纳综合征通常被视为研究早衰的模型。然而，它具有多种临床和病理解剖特征，这使其与正常个体的衰老明显区分开来。在本文中，我们报告了体外细胞遗传学和细胞融合研究，这些研究表明，源自韦尔纳患者的培养成纤维细胞样细胞与正常供体的细胞不同。然而，尽管与“自然”衰老存在这些差异，但韦尔纳综合征与其他几种“节段性早老综合征”一样，可能对研究衰老过程的某些方面以及与年龄相关的疾病有用。
