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放射性脊髓病

Radiation myelopathy.

作者信息

Sanyal B, Pant G C, Subrahmaniyam K, Agrawal M S, Mohanty S

出版信息

J Neurol Neurosurg Psychiatry. 1979 May;42(5):413-8. doi: 10.1136/jnnp.42.5.413.

Abstract

Five cases of radiation myelopathy were found in a total of 10,000 cases given radiotherapy from 1968 to 1977. The clinical presentation and treatment details including the total dose, treatment volume, number of fractionations, overall time, and the RET value at the spinal cord were calculated and compared with other reports on this subject. The total number of fractionations ranged from 20 to 26 with an overall time of 32 days to 37 days. The dose received by four patients ranged from 1030 to 1900 RET, a little higher than the tolerance level of the spinal cord as compared to reported values. Two patients in this series had high blood pressure. The incidence of radiation myelopathy, already acceptably low, could possibly be reduced further by meticulous planning of radiation.

摘要

在1968年至1977年接受放射治疗的10000例患者中,发现了5例放射性脊髓病。计算了临床表现和治疗细节,包括总剂量、治疗体积、分次次数、总时间以及脊髓处的RET值,并与关于该主题的其他报告进行了比较。分次次数总数在20至26次之间,总时间为32天至37天。4例患者接受的剂量范围为1030至1900 RET,与报告值相比略高于脊髓的耐受水平。该系列中有2例患者患有高血压。放射性脊髓病的发生率本已低到可接受的程度,通过精心的放射治疗计划可能会进一步降低。

引用本文的文献

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PET identifies transitional metabolic change in the spinal cord following a subthreshold dose of irradiation.
Pathol Oncol Res. 2004;10(1):42-6. doi: 10.1007/BF02893408. Epub 2004 Mar 18.
2
A very delayed case of post-irradiation myelopathy with unusual features.
Ital J Neurol Sci. 1981 Aug;2(3):311-4. doi: 10.1007/BF02335414.

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