多巴胺受体与人类睡眠诱导

Dopamine receptors and sleep induction in man.

作者信息

Bassi S, Albizzati M G, Frattola L, Passerini D, Trabucchi M

出版信息

J Neurol Neurosurg Psychiatry. 1979 May;42(5):458-60. doi: 10.1136/jnnp.42.5.458.

DOI:10.1136/jnnp.42.5.458

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC490233/

Abstract

Sleep induction has been studied in humans after the administration of apomorphine, a direct stimulant of the central dopaminergic system. The drug induced sleep and vomiting in healthy volunteers while it had no significant effect on 10 Parkinsonism patients treated for a long period with L-dopa. Apomorphine given to a group of Parkinsonism patients not receiving any specific treatment, and with a lower degree of disease severity, induced vomiting and sleep with a pattern similar to that in healthy subjects. A relationship between the dopaminergic system and sleep induction is suggested.

摘要

在给予阿扑吗啡（一种中枢多巴胺能系统的直接兴奋剂）后，对人类的睡眠诱导进行了研究。该药物在健康志愿者中诱发了睡眠和呕吐，而对长期接受左旋多巴治疗的10名帕金森病患者没有显著影响。给一组未接受任何特定治疗且疾病严重程度较低的帕金森病患者服用阿扑吗啡，诱发的呕吐和睡眠模式与健康受试者相似。这表明多巴胺能系统与睡眠诱导之间存在关联。

相似文献

1

Dopamine receptors and sleep induction in man.多巴胺受体与人类睡眠诱导

J Neurol Neurosurg Psychiatry. 1979 May;42(5):458-60. doi: 10.1136/jnnp.42.5.458.

2

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Receptor basis for dopaminergic supersensitivity in Parkinson's disease.帕金森病中多巴胺能超敏反应的受体基础。

Nature. 1978 May 4;273(5657):59-61. doi: 10.1038/273059a0.

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[Apomorphine test: evaluation of dopaminergic response in patients with Parkinson disease].[阿扑吗啡试验：帕金森病患者多巴胺能反应的评估]

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引用本文的文献

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'Sleep attacks' or 'unintended sleep episodes' occur with dopamine agonists: is this a class effect?使用多巴胺激动剂时会出现“睡眠发作”或“意外睡眠事件”：这是一种类效应吗？

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本文引用的文献

1

Dopamine in the mesolimbic system of the rat brain: endogenous levels and the effects of drugs on the uptake mechanism and stimulation of adenylate cyclase activity.大鼠脑边缘系统中的多巴胺：内源性水平以及药物对摄取机制和腺苷酸环化酶活性刺激的影响。

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Injected apomorphine and orally administered levodopa in Parkinsonism.帕金森病中注射用阿扑吗啡与口服左旋多巴

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Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor".大鼠脑尾状核中对多巴胺敏感的腺苷酸环化酶及其与“多巴胺受体”的相似性。

Proc Natl Acad Sci U S A. 1972 Aug;69(8):2145-9. doi: 10.1073/pnas.69.8.2145.

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Apomorphine in Huntington's chorea: clinical observations and theoretical considerations.阿扑吗啡治疗亨廷顿舞蹈病：临床观察与理论思考

Life Sci. 1974 Oct 1;15(7):1371-80. doi: 10.1016/0024-3205(74)90319-1.

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The clinical physiology of side effects in long-term L-DOPA therapy.长期左旋多巴治疗中副作用的临床生理学

Adv Neurol. 1974;5:347-365.

6

Evidence for dopamine receptors mediating sedation in the mouse brain.多巴胺受体介导小鼠大脑镇静作用的证据。

Nature. 1976 Dec 9;264(5586):564-7. doi: 10.1038/264564a0.

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Evidence for dopamine receptors in the human brain mediating sedation and sleep.人类大脑中多巴胺受体介导镇静和睡眠的证据。

Life Sci. 1977 May 1;20(9):1613-8. doi: 10.1016/0024-3205(77)90456-8.

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Central deopaminergic receptor supersensitivity and its relevance to Parkinson's disease.中枢多巴胺能受体超敏反应及其与帕金森病的相关性。

J Neurol Sci. 1977 Jan-Feb;31(1):113-21. doi: 10.1016/0022-510x(77)90009-0.

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Receptor basis for dopaminergic supersensitivity in Parkinson's disease.帕金森病中多巴胺能超敏反应的受体基础。

Nature. 1978 May 4;273(5657):59-61. doi: 10.1038/273059a0.

10

Peptides and behavior.肽与行为。

Life Sci. 1977 Jan 15;20(2):195-204. doi: 10.1016/0024-3205(77)90313-7.

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