Go K G, Gazendam J, van Zanten A K
J Neurosurg. 1979 Jul;51(1):78-84. doi: 10.3171/jns.1979.51.1.0078.
The isolation of edema fluid from cats with cold-induced cerebral edema allowed the study of changes of Na+ and K+ content, lactate dehydrogenase and creatine phosphokinase activity, colloid osmotic pressure and the level of intravenously administered 99mTc-albumin in the edema fluid during a period of hypoxia. The changes consisted of an increase of all mentioned parameters, except Na+; and could be interpreted as a concentration of solutes (but for Na+) in the extracellular edema fluid, concomitant to a reduction of the extracellular space, as the oxygen deficiency caused improper functioning of the cellular Na+-K+ pump, with a resulting shift of fluid (including Na+) into the cellular elements.
从患有冷诱导脑水肿的猫身上分离出的水肿液，使得对缺氧期间水肿液中Na⁺和K⁺含量、乳酸脱氢酶和肌酸磷酸激酶活性、胶体渗透压以及静脉注射的⁹⁹ᵐTc-白蛋白水平的变化进行研究成为可能。这些变化包括除Na⁺之外所有上述参数的增加；并且可以解释为细胞外水肿液中溶质（除Na⁺外）的浓缩，伴随着细胞外空间的减少，因为缺氧导致细胞Na⁺-K⁺泵功能异常，从而导致液体（包括Na⁺）向细胞成分转移。
