Harris G J, Jakobiec F A
J Neurosurg. 1979 Aug;51(2):219-28. doi: 10.3171/jns.1979.51.2.0219.
The clinical and pathological data of 66 patients with orbital cavernous hemangioma are presented. This tumor occurs in females more frequently than in males, and has its peak incidence in early middle age. Visual disability results from a high degree of relative hyperopia or from optic-nerve compression. Postural or temporal variation is proptosis is not characteristic. Multiple cavernous hemangiomas are rare, but may occur simultaneously or separated by long intervals. In this series, incompletely excised lesions did not cause recurrent proptosis. Relative hyperopia may persist, in spite of complete removal of the tumor. Improved preoperative localization with modern techniques appears to be reducing the morbidity associated with surgical excision of the lesion. A local hemodynamic disturbance may initiate proliferation of vascular channels that undergo progressive ectasia. Growth of the lesion may occur intrinsically by the budding-off of capillary channels from cavernous spaces into the interstitium. Clinical and pathological findings fail to demonstrate any relationship between this lesion and capillary hemangioma of childhood.
本文报告了66例眼眶海绵状血管瘤患者的临床及病理资料。该肿瘤在女性中的发生率高于男性，发病高峰在中年早期。视力障碍是由高度相对远视或视神经受压所致。体位性或随时间变化的眼球突出并非其特征性表现。多发性海绵状血管瘤罕见，但可同时发生或间隔很长时间出现。在本系列研究中，未完全切除的病变未导致眼球突出复发。尽管肿瘤已完全切除，但相对远视可能仍然存在。采用现代技术改进术前定位似乎正在降低与病变手术切除相关的发病率。局部血流动力学紊乱可能引发血管通道增生，进而逐渐扩张。病变的生长可能通过从海绵状间隙向间质内芽生毛细血管通道而内在地发生。临床和病理检查结果未能证明该病变与儿童期毛细血管瘤之间存在任何关联。
