Soter N A, Mihm M C, Colten H R
J Pediatr. 1979 Aug;95(2):197-201. doi: 10.1016/s0022-3476(79)80650-2.
Palpable purpura was noted to occur late in the course of some patients with cystic fibrosis. Skin biopsy specimens showed necrotizing venulitis characterized by a perivenular infiltrate composed of neutrophilic leukocytes, fibrin, hypogranulated mast cells, and endothelial cell necrosis. Circulating immune complexes were detected. Recurrent pulmonary infections and the chronic administration of therapeutic agents provide sources of potential antigens.
在一些囊性纤维化患者病程后期可出现可触及的紫癜。皮肤活检标本显示为坏死性小静脉炎，其特征为静脉周围有由嗜中性白细胞、纤维蛋白、颗粒减少的肥大细胞和内皮细胞坏死组成的浸润。检测到循环免疫复合物。反复的肺部感染和长期使用治疗药物提供了潜在抗原的来源。
