Lôo H, Cuche H
Encephale. 1979;5(5 Suppl):591-603.
The antidepressants can be classified chemically. The standard division is between the tricyclic antidepressants and the chemically heterogeneous MAOIs. Many other compounds can be included among the antidepressants, e.g. the bicyclics and possibly also the beta-stimulants, the alpha-blockers and ions such as rubidium. As regards the mechanisms of action, we have the antidepressants which act selectively upon serotonin and those which act more particularly upon noradrenaline. This notion must be extended. Dopamine may be involved in certain depressive syndromes and also other systems may have a role, such as electrolyte systems, cell permeability and the multiple influences which have a bearing upon the monoamines. Finally, the effect upon receptors and their nature are discussed. A third type of classification refers to the therapeutic spectrum of the drug. We have the sedative antidepressants, active in agitated depression and the stimulant antidepressants which are active in retarded depression. However, the two categories of antidepressants have the same global antidepressant action.
抗抑郁药可按化学结构分类。标准分类是三环类抗抑郁药和化学结构各异的单胺氧化酶抑制剂。抗抑郁药还包括许多其他化合物，例如双环类药物，可能还有β-兴奋剂、α-阻滞剂以及铷等离子。关于作用机制，有选择性作用于血清素的抗抑郁药，以及更特别作用于去甲肾上腺素的抗抑郁药。这个概念必须加以扩展。多巴胺可能参与某些抑郁综合征，其他系统也可能起作用，如电解质系统、细胞通透性以及对单胺有影响的多种因素。最后，讨论了药物对受体及其性质的影响。第三种分类方式涉及药物的治疗谱。有在激越性抑郁中起作用的镇静性抗抑郁药，以及在迟滞性抑郁中起作用的兴奋性抗抑郁药。然而，这两类抗抑郁药具有相同的整体抗抑郁作用。
