Matsuo S, Oku Y, Oshibuchi R, Hashiba K
Jpn Heart J. 1979 Jan;20(1):23-32. doi: 10.1536/ihj.20.23.
Indirect systolic time intervals corrected for heart rate were measured at rest, during, and immediately after the isometric handgrip exercise in 70 patients with progressive muscular dystrophy, and these were compared with the values of normal subjects. Those with dystrophy included 47 patients with Duchenne type, 19 with limb girdle type and 4 with facioscapulohumeral type, and each type was subdivided into 2 groups by the severity of the skeletal muscle involvement: 1) mild group, included patients who were still able to walk, 2) severe group, included those who were restricted to wheel chair or confined to bed. Over a half of the patients of the severe Duchenne type group had a longer pre-ejection period (PEP), shorter left ventricular ejection time (LVET), and larger PEP/LVET ratio at rest than the normal group. Increased PEP/LVET ratio during and after isometric handgrip exercise was observed in the severe group of Duchenne type. The patients with limb girdle type, and facioscapulohumeral type showed no significant difference in values of the systolic time intervals at rest and during handgrip exercise compared with the normal subjects. The measurements of resting and exercise systolic time intervals may be useful for clinical recognition of latent left ventricular functional impairement in subjects with progressive muscular dystrophy.
在70例进行性肌营养不良患者静息时、等长握力运动期间及运动后，测量心率校正后的间接收缩期时间间期，并与正常受试者的值进行比较。患有肌营养不良的患者包括47例杜氏型、19例肢带型和4例面肩肱型，每种类型根据骨骼肌受累程度再分为2组：1）轻度组，包括仍能行走的患者；2）重度组，包括那些只能坐轮椅或卧床的患者。重度杜氏型组超过一半的患者静息时的射血前期（PEP）较长、左心室射血时间（LVET）较短、PEP/LVET比值较大，高于正常组。在杜氏型重度组中，等长握力运动期间及运动后观察到PEP/LVET比值增加。肢带型和面肩肱型患者静息时及握力运动期间收缩期时间间期的值与正常受试者相比无显著差异。静息和运动时收缩期时间间期的测量可能有助于临床上识别进行性肌营养不良患者潜在的左心室功能损害。
