二苯乙内酰脲对鱿鱼巨轴突钠电导的抑制作用。
Diphenylhydantoin inhibition of sodium conductance in squid giant axon.
作者信息
Lipicky R J, Gilbert D L, Stillman I M
出版信息
Proc Natl Acad Sci U S A. 1972 Jul;69(7):1758-60. doi: 10.1073/pnas.69.7.1758.
Abstract
Diphenylhydantoin, in concentration of 5-50 muM, decreases the early, transient (sodium) currents of voltage-clamped squid giant axons. These effects are dose-dependent and largely reversible. It appears that diphenylhydantoin reduces the number of open, early, transient (sodium) channels.
摘要
苯妥英钠在浓度为5 - 50微摩尔时，可降低电压钳制的枪乌贼巨大轴突的早期瞬态（钠）电流。这些效应呈剂量依赖性且在很大程度上是可逆的。苯妥英钠似乎减少了开放的早期瞬态（钠）通道的数量。
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