氟离子催化嘌呤、嘧啶、核苷和核苷酸与卤代烃的烷基化反应。
Fluoride ion catalyzed alkylation of purines, pyrimidines, nucleosides and nucleotides using alky halides.
作者信息
Ogilvie K K, Beaucage S L, Gillen M F, Entwistle D, Quilliam M
出版信息
Nucleic Acids Res. 1979 Apr;6(4):1695-708. doi: 10.1093/nar/6.4.1695.
Abstract
Alkyl halides react rapidly with purines and pyrimidines in the presence of fluoride ion. Alkylation of thymidine leads to novel dimeric nucleoside derivatives bridged through N3. Alkylation of thymidine mono and dinucleotides leads to alkylation at the base (N3) as well as diester and triester formation at the phosphate.
摘要
在氟离子存在下，卤代烷与嘌呤和嘧啶迅速反应。胸苷的烷基化导致通过N3桥连的新型二聚核苷衍生物。胸苷单核苷酸和二核苷酸的烷基化导致碱基（N3）处的烷基化以及磷酸酯处的二酯和三酯形成。
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Fluoride ion catalyzed alkylation of purines, pyrimidines, nucleosides and nucleotides using alky halides.氟离子催化嘌呤、嘧啶、核苷和核苷酸与卤代烃的烷基化反应。
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引用本文的文献
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Fluoride ion catalyzed alkylation of nucleic acid derivatives using trialkyl phosphates, dialkyl sulfates and alkyl methanesulfonates.氟离子催化的使用磷酸三烷基酯、硫酸二烷基酯和甲磺酸烷基酯的核酸衍生物的烷基化反应。
Nucleic Acids Res. 1979;6(6):2261-73. doi: 10.1093/nar/6.6.2261.
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