核酸相互作用的简单模型2. “桥连”核苷的氨酰基衍生物：2'(3')-O-L-苯丙氨酰基-和2'(3')-O-L-亮氨酰基-1,2-二(腺苷-N6-基)乙烷的合成 - Suppr | 超能文献

Simple models of nucleic acid interactions 2. Aminoacyl derivatives of "bridged" nucleosides: Synthesis of 2'(3')-O-L-phenylalanyl- and 2'(3')-O-L-leucyl-1,2-di(adenosin-N6-yl)ethane.

作者信息

Li C, Zemlicka J

出版信息

J Org Chem. 1977 Feb 18;42(4):706-11. doi: 10.1021/jo00424a029.

DOI:10.1021/jo00424a029

Abstract

摘要

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Simple models of nucleic acid interactions 2. Aminoacyl derivatives of "bridged" nucleosides: Synthesis of 2'(3')-O-L-phenylalanyl- and 2'(3')-O-L-leucyl-1,2-di(adenosin-N6-yl)ethane.核酸相互作用的简单模型2. “桥连”核苷的氨酰基衍生物：2'(3')-O-L-苯丙氨酰基-和2'(3')-O-L-亮氨酰基-1,2-二(腺苷-N6-基)乙烷的合成

J Org Chem. 1977 Feb 18;42(4):706-11. doi: 10.1021/jo00424a029.

2

Aminoacyl derivatives of "bridged" nucleosides: chemical synthesis and substrate activity of 2'(3')-O-(N-acetyl)-L-leucyl-2''(3'')-O-L-phenylalanyl-(1,2-diadenosin-N6-yl)ethane, a spacer probe for ribosomal peptidyltransferase.

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3

Simple models of nucleic acid interactions. 1. Base--base interactions in 1,2-Di)adenosin-N6-yl)ethane and 1,4-Di(adenosin-N6-yl)butane.核酸相互作用的简单模型。1. 1,2-二（腺苷-N6-基）乙烷和1,4-二（腺苷-N6-基）丁烷中的碱基-碱基相互作用。

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4

Inhibition of ribosomal peptidyltransferase with 2'(3')-O-acetyl-2 inches(3 inches)-O-glycyl-1,2-di(adenosin-N6-yl)ethane and -1,4-di(adenosin-N6-yl)butane. Effect of alkyl chain length.用2'（3'）-O-乙酰基-2英寸（3英寸）-O-甘氨酰-1,2-二（腺苷-N6-基）乙烷和-1,4-二（腺苷-N6-基）丁烷抑制核糖体肽基转移酶。烷基链长度的影响。

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Synthesis of dicytidylyl-(3'-5')-1,2-di(adenosin-N6-yl)ethane and dicytidylyl-(3'-5')-1,4-di(adenosin-N6-yl)butane: covalently joined terminals of two transfer ribonucleic acids and their behavior toward snake venom phosphodiesterase.二胞苷酰基-（3'-5'）-1,2-二（腺苷-N6-基）乙烷和二胞苷酰基-（3'-5'）-1,4-二（腺苷-N6-基）丁烷的合成：两个转移核糖核酸的共价连接末端及其对蛇毒磷酸二酯酶的反应

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2'(3')-O-L-Aminoacyl derivatives of "bridged" adenine ribonucleosides as substrates for fibosomal peptidyltransferase.“桥连”腺嘌呤核糖核苷的2'（3'）-O-L-氨基酰基衍生物作为核糖体肽基转移酶的底物。

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7

Substrate specificity of ribosomal peptidyltransferase. Effect of modification in the heterocyclic, carbohydrate and amino acid moiety of 2'(3')-O-L-phenylalanyladenosine.核糖体肽基转移酶的底物特异性。2'（3'）-O-L-苯丙氨酰腺苷的杂环、碳水化合物和氨基酸部分修饰的影响。

Biochemistry. 1975 Dec 2;14(24):5239-49. doi: 10.1021/bi00695a001.

8

A simple and efficient synthesis of puromycin, 2,2'-anhydro-pyrimidine nucleosides, cytidines and 2',3'-anhydroadenosine from 3',5'-O-sulfinyl xylo-nucleosides.一种从3',5'-O-亚磺酰木糖核苷简单高效合成嘌呤霉素、2,2'-脱水嘧啶核苷、胞苷和2',3'-脱水腺苷的方法。

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2'(3')-O-L-(O-methyl-3-phenyllactyl) adenosine. A potential analog of 2'(3')-O-aminoacyl ribonucleosides.2'（3'）-O-L-（O-甲基-3-苯基乳酰基）腺苷。一种2'（3'）-O-氨基酰基核糖核苷的潜在类似物。

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10

Adenosine derivatives with N6-alkyl, -alkylamine or -alkyladenosine substituents as probes for the A1-receptor.具有N6-烷基、-烷基胺或-烷基腺苷取代基的腺苷衍生物作为A1受体的探针。

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引用本文的文献

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Fluoride ion catalyzed alkylation of purines, pyrimidines, nucleosides and nucleotides using alky halides.氟离子催化嘌呤、嘧啶、核苷和核苷酸与卤代烃的烷基化反应。

Nucleic Acids Res. 1979 Apr;6(4):1695-708. doi: 10.1093/nar/6.4.1695.