溶液中乙酰胆碱类似物与局部麻醉剂类似物之间的构象关系。
Conformational relationships between analogs of acetylcholine and those of local anesthetics in solution.
作者信息
Makriyannis A, Sullivan R F, Mautner H G
出版信息
Proc Natl Acad Sci U S A. 1972 Nov;69(11):3416-9. doi: 10.1073/pnas.69.11.3416.
Abstract
Conformations of analogs of acetylcholine and of related local anesthetics, in which either of the oxygen atoms had been replaced by other heteroatoms, were studied in solution by nuclear magnetic resonance. Several correlations between structure and conformation could be made.
摘要
通过核磁共振对乙酰胆碱类似物以及相关局部麻醉剂的构象进行了研究，这些类似物中两个氧原子中的任何一个都已被其他杂原子取代。可以建立结构与构象之间的几种关联。
相似文献
1
Conformational relationships between analogs of acetylcholine and those of local anesthetics in solution.溶液中乙酰胆碱类似物与局部麻醉剂类似物之间的构象关系。
Proc Natl Acad Sci U S A. 1972 Nov;69(11):3416-9. doi: 10.1073/pnas.69.11.3416.
2
[Propynoxy-2-benzamides and analogs].[炔丙氧基-2-苯甲酰胺及其类似物]
Experientia. 1962 Jul 15;18:319-20. doi: 10.1007/BF02151851.
3
Molecular properties of local anesthetics: the crystal structure of 2-diethylaminoethyl p-methoxybenzoate hydrochloride.局部麻醉药的分子特性：盐酸对甲氧基苯甲酸2-二乙氨基乙酯的晶体结构
Biochem Biophys Res Commun. 1970 Aug 24;40(4):833-8. doi: 10.1016/0006-291x(70)90978-2.
4
[The local anesthetic properties of N-alkylaminoalkyl-o-alkoxy-benzamides. 2. N-Pyrrolidinylethyl-o-alkoxybenzamides].
Arzneimittelforschung. 1961 Aug;11:801-6.
5
Antiacetylcholine, antiaccelerator and local anaesthetic activity of some quinidine like drugs.某些类奎尼丁药物的抗乙酰胆碱、抗加速剂及局部麻醉活性
Arch Int Pharmacodyn Ther. 1962 Jun 1;137:410-27.
6
A new approach to empirical intermolecular and conformational potential energy functions. II. Applications to crystal packing, rotational barriers, and conformational analysis.一种经验性分子间和构象势能函数的新方法。II. 在晶体堆积、旋转势垒和构象分析中的应用。
Proc Natl Acad Sci U S A. 1975 Mar;72(3):854-8. doi: 10.1073/pnas.72.3.854.
7
The time dependent UV resonance Raman spectra, conformation, and biological activity of acetylcholine analogues upon binding to acetylcholine binding proteins.乙酰胆碱类似物与乙酰胆碱结合蛋白结合后的时间依赖性紫外共振拉曼光谱、构象及生物活性
J Biomol Struct Dyn. 1991 Dec;9(3):489-509. doi: 10.1080/07391102.1991.10507931.
8
Absolute configuration and local anaesthetic activity of cis and trans 2-dimethylaminomethyl-cyclohexyl benzoates.
Arzneimittelforschung. 1988 Aug;38(8):1081-4.
9
Anion complexation with cyanobenzoyl substituted first and second generation tripodal amide receptors: crystal structure and solution studies.阴离子与氰基苯甲酰基取代的第一代和第二代三脚架酰胺受体的络合作用：晶体结构与溶液研究
Dalton Trans. 2015 Sep 14;44(34):15220-31. doi: 10.1039/c5dt00369e.
引用本文的文献
1
End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease.终板乙酰胆碱受体：结构、机制、药理学和疾病。
Physiol Rev. 2012 Jul;92(3):1189-234. doi: 10.1152/physrev.00015.2011.
2
Acetylcholine-like molecular arrangement in psychomimetic anticholinergic drugs.拟精神病性抗胆碱能药物中的乙酰胆碱样分子排列
Proc Natl Acad Sci U S A. 1973 Nov;70(11):3103-7. doi: 10.1073/pnas.70.11.3103.
本文引用的文献
1
ANALOGS OF PARASYMPATHETIC NEUROEFFECTORS. I. ACETYLSELENOCHOLINE, SELENOCHOLINE, AND RELATED COMPOUNDS.副交感神经效应器类似物。I. 乙酰硒胆碱、硒胆碱及相关化合物。
J Med Chem. 1964 Mar;7:229-32. doi: 10.1021/jm00332a023.
2
Metabolism and function of the nerve cell.神经细胞的代谢与功能。
Harvey Lect. 1953;49:57-99.
3
Structure of acetylcholine and other substrates of cholinergic systems.
Nature. 1966 May 28;210(5039):907-9. doi: 10.1038/210907a0.
4
Relationship between acetylcholine and local anesthetics.
Biochim Biophys Acta. 1965 Sep 27;109(1):194-203. doi: 10.1016/0926-6585(65)90103-2.
5
Molecular structure determining the action of local anesthetics on the acetylcholine receptor.决定局部麻醉药对乙酰胆碱受体作用的分子结构。
Biochem Z. 1965 Aug 19;342(4):359-74.
6
Sulfur and selenium compounds related to acetylcholine and choline. VII. Isologs of benzoylthionocholine and of 2-dimethylaminoethyl thionobenzoate.与乙酰胆碱和胆碱相关的硫和硒化合物。VII. 苯甲酰硫代胆碱和硫代苯甲酸2-二甲基氨基乙酯的同系物。
J Med Chem. 1968 May;11(3):446-50. doi: 10.1021/jm00309a006.
7
Conformation of some acetylcholine analogs as solutes in deuterium oxide and other solvents.
J Pharm Sci. 1971 Jan;60(1):67-73. doi: 10.1002/jps.2600600112.
8
Sulfur and selenium compounds related to acetylcholine and choline. X. Acetylhionocholine.
J Med Chem. 1970 Mar;13(2):214-5. doi: 10.1021/jm00296a011.
9
Molecular properties of local anesthetics: the crystal structure of procaine hydrochloride.局部麻醉药的分子特性：盐酸普鲁卡因的晶体结构
Biochem Biophys Res Commun. 1970 May 11;39(3):329-34. doi: 10.1016/0006-291x(70)90580-2.
10
Acetylcholine and its thiolester and selenolester analogs: conformation, electron distribution, and biological activity.乙酰胆碱及其硫酯和硒酯类似物：构象、电子分布和生物活性。
Proc Natl Acad Sci U S A. 1969 Aug;63(4):1253-60. doi: 10.1073/pnas.63.4.1253.
Zotero 插件