乙酰胆碱及其硫酯和硒酯类似物：构象、电子分布和生物活性。
Acetylcholine and its thiolester and selenolester analogs: conformation, electron distribution, and biological activity.
作者信息
Shefter E, Mautner H G
出版信息
Proc Natl Acad Sci U S A. 1969 Aug;63(4):1253-60. doi: 10.1073/pnas.63.4.1253.
Abstract
The crystal structures of acetylthiolcholine bromide and propionylthiolcholine iodide were elucidated. Acetylthiolcholine was found to be essentially isosteric with acetylselenolcholine, while the conformation of these compounds was quite different from that of acetylcholine. The importance of conformation and electron distribution in the biological actions of choline esters is discussed.
摘要
阐明了溴化乙酰硫代胆碱和碘化丙酰硫代胆碱的晶体结构。发现乙酰硫代胆碱与乙酰硒代胆碱基本等排，而这些化合物的构象与乙酰胆碱的构象有很大不同。讨论了胆碱酯生物活性中构象和电子分布的重要性。
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本文引用的文献
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ANALOGS OF PARASYMPATHETIC NEUROEFFECTORS. I. ACETYLSELENOCHOLINE, SELENOCHOLINE, AND RELATED COMPOUNDS.副交感神经效应器类似物。I. 乙酰硒胆碱、硒胆碱及相关化合物。
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ANALOGS OF PARASYMPATHETIC NEUROEFFECTORS. II. COMPARATIVE PHARMACOLOGICAL STUDIES OF ACETYLCHOLINE, ITS THIO AND SELENO ANALOGS, AND THEIR HYDROLYSIS PRODUCTS.副交感神经效应器类似物。II. 乙酰胆碱及其硫代和硒代类似物及其水解产物的比较药理学研究。
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Chemistry and pharmacology of muscarine, muscarone, and some related compounds.毒蕈碱、毒蝇蕈酮及一些相关化合物的化学与药理学
Pharmacol Rev. 1961 Dec;13:465-515.
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Metabolism and function of the nerve cell.神经细胞的代谢与功能。
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Sulfur and selenium isologs related to acetylcholine and choline. IX. Further comparative studies of the pharmacological effects of acetylcholine and its thio and seleno analogs and their hydrolysis products.与乙酰胆碱和胆碱相关的硫和硒类似物。IX. 乙酰胆碱及其硫代和硒代类似物及其水解产物药理作用的进一步比较研究。
Biochem Pharmacol. 1967 Oct;16(10):1903-18. doi: 10.1016/0006-2952(67)90301-2.
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