登革病毒对仓鼠西尼罗河病毒的交叉保护机制。
The mechanism of cross-protection afforded by dengue virus against West Nile virus in hamsters.
作者信息
Price W H, Thind I S
出版信息
J Hyg (Lond). 1972 Dec;70(4):611-7. doi: 10.1017/s0022172400022476.
Abstract
The protection afforded by similar concentrations of different dengue virus serotypes against a subsequent challenge of West Nile virus was studied in hamsters. The New Guinea C strain of dengue 2 virus gave the best protection. It was found that the anamnestic neutralizing antibody response induced by the challenge West Nile virus against West Nile virus in hamsters, previously immunized with dengue 2 virus, might play a major role in the cross-protection observed in this system.
摘要
在仓鼠中研究了不同登革病毒血清型的相似浓度对西尼罗河病毒后续攻击的保护作用。登革2病毒的新几内亚C株提供了最佳保护。研究发现，先前用登革2病毒免疫的仓鼠，受到西尼罗河病毒攻击后诱导产生的回忆性中和抗体反应，可能在该系统中观察到的交叉保护中起主要作用。
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