Bliznakov E G
Proc Natl Acad Sci U S A. 1973 Feb;70(2):390-4. doi: 10.1073/pnas.70.2.390.
Members of the coenzyme Q group increase the phagocytic activity in rats, as measured by the carbon clearance technique, and increase the hemolytic antibody formation in mice. In addition, prior treatment with low doses of chloroquine hydrochloride combined with coenzyme Q(10) results in increased numbers of survivors, prolonged survival time, and reduced parasitemia in blood-transferred Plasmodium berghei infection in miceIn an extension of these studies, using emulsions of coenzyme Q(10), I demonstrated the following effects on two tumor systems in mice: (i) Treatment with coenzyme Q(10) decreased splenomegaly and hepatomegaly and increased the number of surviving mice infected with Friend leukemia virus. (ii) Treatment with coenzyme Q(10) reduced the percentage of mice with tumors, increased the number of survivors, and reduced the tumor size in mice with tumors induced by 3,4,9,10-dibenzpyrene. The effect on both tumor systems was dose-dependent. These studies support the hypothesis that the host defense system plays a definitive role in the defense of the host against invasion by various agents, including neoplasia.
通过碳清除技术测定，辅酶Q组的成员可提高大鼠的吞噬活性，并增加小鼠溶血抗体的形成。此外，先用低剂量盐酸氯喹与辅酶Q10联合治疗，可使感染伯氏疟原虫的小鼠存活数量增加、存活时间延长且血中疟原虫血症减少。在这些研究的拓展中，我使用辅酶Q10乳剂，证明了其对小鼠的两种肿瘤系统有以下作用：（i）用辅酶Q10治疗可减轻脾脏肿大和肝脏肿大，并增加感染弗氏白血病病毒的存活小鼠数量。（ii）用辅酶Q10治疗可降低患肿瘤小鼠的比例，增加存活数量，并减小由3,4,9,10-二苯并芘诱导产生肿瘤的小鼠的肿瘤大小。对两种肿瘤系统的作用均呈剂量依赖性。这些研究支持了宿主防御系统在宿主抵御包括肿瘤形成在内的各种病原体入侵中起决定性作用这一假说。
