酶的温度适应性：活化自由能、焓和熵的作用。
Temperature adaptation of enzymes: roles of the free energy, the enthalpy, and the entropy of activation.
作者信息
Low P S, Bada J L, Somero G N
出版信息
Proc Natl Acad Sci U S A. 1973 Feb;70(2):430-2. doi: 10.1073/pnas.70.2.430.
Abstract
The enzymic reactions of ectothermic (cold-blooded) species differ from those of avian and mammalian species in terms of the magnitudes of the three thermodynamic activation parameters, the free energy of activation (DeltaG()), the enthalpy of activation (DeltaH()), and the entropy of activation (DeltaS()). Ectothermic enzymes are more efficient than the homologous enzymes of birds and mammals in reducing the DeltaG() "energy barrier" to a chemical reaction. Moreover, the relative importance of the enthalpic and entropic contributions to DeltaG() differs between these two broad classes of organisms.
摘要
变温（冷血）物种的酶促反应在三个热力学活化参数的大小方面与鸟类和哺乳动物物种不同，这三个参数分别是活化自由能（ΔG()）、活化焓（ΔH()）和活化熵（ΔS()）。变温动物的酶在降低化学反应的ΔG()“能量屏障”方面比鸟类和哺乳动物的同源酶更有效。此外，在这两大类生物中，焓和熵对ΔG()的贡献的相对重要性也有所不同。
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