Virgo B B
Res Commun Chem Pathol Pharmacol. 1979 Jul;25(1):65-77.
The estrogenicity of THC was assessed in three estrogen-sensitive systems. The drug did not block implantation when injected (s.c.) on Day 0 of pregnancy: on Day 6, 95% (3 mg/kg) and 86% (12 mg/kg) of the mice had embryos as did 96% (P greater than 0.1) of the controls; implantation occurred in only 9% (P less than 0.005) of mice treated similarly with estradiol (E2; 0.15 mg/kg). Nor did THC induce implantation: pregnant mice were ovariectomized on Day 1, treated daily with progesterone (2 mg, s.c.) and injected (i.p.) with THC on Day 3: at mg THC/kg 39% had embryos, as did 41% of those at 6 mg/kg; these rates do not differ (P greater than 0.99) from that of the controls (38%); in contrast, ova implanted in 75% (P less than 0.025) of E2-treated mice (4.0 microgram/kg). The average number of implanting ova was the same in all groups in both experiments. THC did not cause uterine hypertrophy: ovariectomized mice were injected (s.c.) for 14 days with THC (3 or 6 mg/kg) or E2(2 microgram/kg): the uterine weight, total uterine protein and total uterine glycogen of the ovariectomized controls was 24 +/- 2 mg, 3 +/- 0.3 mg and 11 +/- 3 mg respectively and the values for the THC-treated mice were not different (P greater than 0.05); in contrast, E2 increased (P less than 0.01) uterine weight to 139 +/- 9 mg, uterine protein to 5 +/- 0.6 mg and uterine glycogen to 62 +/- 8 mg. It is concluded that THC is not estrogenic.
在三个雌激素敏感系统中评估了四氢大麻酚（THC）的雌激素活性。在妊娠第0天皮下注射该药物时，它并未阻止着床：在第6天，95%（3毫克/千克）和86%（12毫克/千克）的小鼠有胚胎，对照组为96%（P大于0.1）；用雌二醇（E2；0.15毫克/千克）进行类似处理的小鼠中只有9%发生着床（P小于0.005）。THC也未诱导着床：妊娠小鼠在第1天进行卵巢切除，每天皮下注射孕酮（2毫克），并在第3天腹腔注射THC：3毫克THC/千克组中有39%有胚胎，6毫克/千克组为41%；这些比率与对照组（38%）无差异（P大于0.99）；相比之下，E2处理组（4.0微克/千克）中有75%发生卵子着床（P小于0.025）。在两个实验的所有组中，着床卵子的平均数量相同。THC未引起子宫肥大：对卵巢切除的小鼠皮下注射THC（3或6毫克/千克）或E2（2微克/千克）14天：卵巢切除对照组的子宫重量、子宫总蛋白和子宫总糖原分别为24±2毫克、3±0.3毫克和11±3毫克，THC处理小鼠的值无差异（P大于0.05）；相比之下，E2使子宫重量增加（P小于0.01）至139±9毫克，子宫蛋白增加至5±0.6毫克，子宫糖原增加至62±8毫克。结论是THC不具有雌激素活性。
