玛卡（秘鲁人参）可增加正常成年雌性小鼠的产仔数。
Lepidium meyenii (Maca) increases litter size in normal adult female mice.
作者信息
Ruiz-Luna Ana C, Salazar Stephanie, Aspajo Norma J, Rubio Julio, Gasco Manuel, Gonzales Gustavo F
机构信息
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru.
出版信息
Reprod Biol Endocrinol. 2005 May 3;3:16. doi: 10.1186/1477-7827-3-16.
BACKGROUND
Lepidium meyenii, known as Maca, grows exclusively in the Peruvian Andes over 4000 m altitude. It has been used traditionally to increase fertility. Previous scientific studies have demonstrated that Maca increases spermatogenesis and epididymal sperm count. The present study was aimed to investigate the effects of Maca on several fertility parameters of female mice at reproductive age.
METHODS
Adult female Balb/C mice were divided at random into three main groups: i) Reproductive indexes group, ii) Implantation sites group and iii) Assessment of uterine weight in ovariectomized mice. Animals received an aqueous extract of lyophilized Yellow Maca (1 g/Kg BW) or vehicle orally as treatment. In the fertility indexes study, animals received the treatment before, during and after gestation. The fertility index, gestation index, post-natal viability index, weaning viability index and sex ratio were calculated. Sexual maturation was evaluated in the female pups by the vaginal opening (VO) day. In the implantation study, females were checked for implantation sites at gestation day 7 and the embryos were counted. In ovariectomized mice, the uterine weight was recorded at the end of treatment.
RESULTS
Implantation sites were similar in mice treated with Maca and in controls. All reproductive indexes were similar in both groups of treatment. The number of pups per dam at birth and at postnatal day 4 was significantly higher in the group treated with Maca. VO day occurred earlier as litter size was smaller. Maca did not affect VO day. In ovariectomized mice, the treatment with Maca increased significantly the uterine weights in comparison to their respective control group.
CONCLUSION
Administration of aqueous extract of Yellow Maca to adult female mice increases the litter size. Moreover, this treatment increases the uterine weight in ovariectomized animals. Our study confirms for the first time some of the traditional uses of Maca to enhance female fertility.
背景
玛咖，即秘鲁独行菜，仅生长于秘鲁安第斯山脉海拔4000米以上地区。传统上它被用于提高生育能力。此前的科学研究表明，玛咖可增加精子发生及附睾精子数量。本研究旨在探究玛咖对育龄雌性小鼠若干生育参数的影响。
方法
成年雌性Balb/C小鼠被随机分为三个主要组：i）生殖指标组，ii）着床点组，iii）去卵巢小鼠子宫重量评估组。动物口服冻干黄玛咖水提取物（1克/千克体重）或赋形剂作为治疗。在生育指标研究中，动物在妊娠前、妊娠期间及妊娠后接受治疗。计算生育指数、妊娠指数、产后存活指数、断奶存活指数及性别比。通过阴道开口日评估雌性幼崽的性成熟情况。在着床研究中，于妊娠第7天检查雌性小鼠的着床点并计数胚胎。在去卵巢小鼠中，治疗结束时记录子宫重量。
结果
玛咖治疗组小鼠的着床点与对照组相似。两组治疗的所有生殖指标均相似。玛咖治疗组每只母鼠出生时及出生后第4天的幼崽数量显著更高。随着窝仔数减少，阴道开口日出现得更早。玛咖不影响阴道开口日。在去卵巢小鼠中，与各自对照组相比，玛咖治疗显著增加了子宫重量。
结论
给成年雌性小鼠施用黄玛咖水提取物可增加窝仔数。此外，该治疗增加了去卵巢动物的子宫重量。我们的研究首次证实了玛咖在提高雌性生育能力方面的一些传统用途。
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