Huang C T, Heurich A E, Rosen Y, Moon S, Lyons H A
Respiration. 1979;37(6):337-45. doi: 10.1159/000194046.
Discrepancies were observed between functional (PFT), chest roentgenographic, and open lung biopsy findings (granulomata, interstitial pneumonitis, angiitis, and fibrosis) in 81 patients with clinical diagnosis of sarcoidosis. A combination of normal PFT and Type 1 roentgenographic findings (hilar lymphadenopathy) was associated with minimal lung lesions without fibrosis. Type 1 findings alone did not preclude extensive lesions or fibrosis. Advanced roentgenographic and PFT abnormalities correlated with the presence of extensive lung lesions. The pulmonary diffusing capacity correlated best with specific and overall lung pathology, and roentgenographic types. Only this test differentiated the extent of granulomata and the roentgenographic types. Moderate degrees of other pathologic changes were not distinguished by any other PFT. Degrees of overall lung pathology correlated with an individual PFT and most significantly with overall PFT (p less than 0.001). Serial studies of PFT are a practical and valuable means for assessment of the disease process in sarcoidosis.
在81例临床诊断为结节病的患者中，观察到功能检查（肺功能测试）、胸部X线检查结果与开胸肺活检结果（肉芽肿、间质性肺炎、血管炎和纤维化）之间存在差异。肺功能测试正常且X线表现为1型（肺门淋巴结肿大）的情况与无纤维化的轻微肺部病变相关。仅1型表现并不能排除广泛病变或纤维化。晚期X线和肺功能测试异常与广泛肺部病变的存在相关。肺弥散能力与特定及整体肺部病理以及X线类型的相关性最佳。只有这项检查能区分肉芽肿的程度和X线类型。其他肺功能测试无法区分中度程度的其他病理变化。整体肺部病理程度与个体肺功能测试相关，与整体肺功能测试的相关性最为显著（p小于0.001）。肺功能测试的系列研究是评估结节病疾病进程的实用且有价值的方法。
